Abstract: Objective This study aimed to retrospectively evaluate the efficacy and safety of balloon-occluded retrograde transvenous obliteration (BRTO) in patients with hepatitis B-induced liver cirrhosis (LC) complicated by gastric varices (GV). Methods A total of 101 patients with hepatitis B-induced LC and complicated GV were encountered in our hospital between January 2022 and June 2024, and were randomly divided into two groups, underwent BRTO in observation group (n=51) or transjugular intrahepatic portosystemic shunt (TIPS) in control group (n=50). All patients were followed-up for one year after operation. Results By end of three-month of follow-up, eradication rate of GV in the observation group was 84.3% and second BRTO eradicated all GV, while GV disappeared in 5 cases (10.0%, P<0.05) in the control; by end of six-month of follow-up, two patients in the observation and four patients in the control died; by end of one-year of follow-up, three cases in BRTO-treated patients and five cases in TIPS-treated died; after operations, the liver function tests and hypersplenism didn’t improved and the related parameter were not significantly different between the two groups(P>0.05). Conclusion BRTO demonstrates safe and a favorable GV eradication rate in the treatment of patients with hepatitis B-induced LC, which might needs sophisticated procedural skills, and the long-term efficacy on prophylactic GV bleeding is still observed.

Key words: Liver cirrhosis, Gastric varices, Balloon-occluded retrograde transvenous obliteration, Transjugular intrahepatic portosystemic shunt, Therapy