Abstract: Objective The aim of this study was to investigate intrapurulent catheter drainage under ultrasound guidance in the treatment of patients with bacterial liver abscess (BLA). Method A total of 96 patients with BLA were encountered in our hospital between October 2020 and October 2023, and were randomly divided into observation group (n=48) and control group (n=48), received intrapurulent catheter drainage or puncture drainage under ultrasound guidance. Supporting management was given in the two groups. Serum malondialdehyde (MDA), superoxide dismutase (SOD) and cortisol (COR) levels were assayed by ELISA, and serum interleukin-6 (IL-6),IL-8 and IL-12 levels were also detected by ELISA. Result All patients with BLA recovered in our series after one to three week treatment, presenting with disappeared purulent cavity, and no relapse was found by end of three month follow-up; after treatment, serum bilirubin, ALT and GGT levels in the observation group were(15.3±2.4)μmol /L, (72.4±7.5)U/L, (39.3±2.8)g/L and (79.3±19.4)U/L, all not significantly different compared to [(16.5±2.3)μmol /L, (73.2±10.3)U/L, (36.6±2.9)g/L and (73.1±22.3)U/L, respectively] in the control (P>0.05); serum SOD, COR and MDA levels in the observation were (73.3±7.5)U/mL, (117.8±8.4)nmol/L and (5.1±0.8)μmol/mL, all not significantly different as compared to [(75.4±7.1)U/mL, (118.8±8.5)nmol/L and (5.5±0.9)μmol/mL, respectively] in the control group (P>0.05); serum IL-6, IL-8and IL-12 levels in the observation were (0.2±0.1)ng/mL, (0.3±0.1)ng/mL and (81.3±16.5)ng/mL, all much lower than [(0.3±0.1)ng/mL, 0.4±0.1)ng/mL and (95.2±17.1)ng/mL, respectively, P＜0.05] in the control group. Conclusion We recommend intrapurulent catheter drainage under ultrasound guidance in dealing with patients with BLA, which might need less puncture and less antibiotic administration, with relatively quick recovery.

Key words: Bacterial liver abscess, Ultrasound guidance, Intrapurulent catheter drainage, Cytokines, Therapy