Abstract: Objective The aim of this study was to investigate acupoint application and exercise prescription in the treatment of patients with non-alcoholic fatty liver disease (NAFLD). Methods 81 patients with NAFLD were encountered in our hospitalbetween June 2022 and June 2024, and were randomly divided into control group (n=40) and observation group (n=41). Patients in the control group received lipid-lowering therapy with dietary intervention, and those in the observation received acupoint application and exercise prescription. The intervention lasted for three months in the two groups. Serumtumor necrosis factor-α(TNF-α), interleukin 6 (IL-6), irisin and adiponectin (APN) levels were detected by ELISA, controlled attenuation parameter (CAP) was determined byFibrotouch, and generic quality of life inventory 74 (GQOLI-74) and health promoting lifestyle profile (HPLP)were evaluated. Results By end of three month intervention, body mass index, waist-to-hip ratio and ,WHR and percentage of body fat in the observation group were(24.3±2.6)kg/m², (0.6±0.2)and (27.3±2.8)%, all much lower than [(26.1±2.7)kg/m², (0.7±0.1)and (29.6±3.1)%,P<0.05] in the control; serum total cholesterol,triacylglycerol and low-density lipoprotein cholesterol levels were(5.5±0.7)mmol/L, (1.7±0.3)mmol/Land (3.2±0.5)mmol/L, all much lower than[(5.9±0.7)mmol/L, (2.6±0.4)mmol/L and (4.2±0.5)mmol/L, respectively, P<0.05], while serum high-density lipoprotein cholesterol level was(1.3±0.4)mmol/L, much higher than [(1.0±0.3) mmol/L,P<0.05] in the control; serumalanine aminotransferase,aspartate aminotransferase and CAP were(40.3±4.5)IU/L, (42.1±4.6)IU/L and (267.8±7.8)dB/m, all significantly lower than[(93.4±5.6)IU/L, (61.7±5.9)IU/Land (288.3±10.9)dB/m, respectively, P<0.05] in the control; serum TNF-α and IL-6 levels were(401.5±42.3)pg/mL and (18.6±2.8)mg/L, both significantly lower than [(461.2±48.6)pg/mLand (28.7±3.1)mg/L, respectively, P<0.05], while serum irisin and APN levels were (9.4±1.2)ng/mL and (19.3±2.1)μg/mL, both significantly higher than[(7.6±0.9)ng/mLand (13.4±1.8)μg/mL, respectively,P<0.05] in the control group; GQOLI-74 score, and regular exercise, scientific dietand adequate sleep rates were(81.2±8.5)points, and 87.8%, 85.4%and 82.9%, all much higher than [(76.3±7.6)points, 62.5%, 60.0%and 62.5%, respectively, P<0.05] in the control. Conclusion Acupoint application and exercise prescription is efficacious in the treatment ofpatients with NAFLD,which might improve body fat metabolism and alleviate inflammatory reactions.

Key words: Non-alcoholic fatty liver disease, Acupoint application, Exercise prescription, Controlled attenuation parameter, Therapy