- ISSN 1672-5069
- CN 34-1270/R
- CODEN SGZHBF
Journal of Practical Hepatology ›› 2025, Vol. 28 ›› Issue (3): 321-325.doi: 10.3969/j.issn.1672-5069.2025.03.001
Chen Chunru, Qi Haolong, Lu Cong, et al
Received:2024-11-20
Published:2025-05-14
Chen Chunru, Qi Haolong, Lu Cong, et al. Impact of circadian rhythms on pathogenesis of non-alcoholic fatty liver disease[J]. Journal of Practical Hepatology, 2025, 28(3): 321-325.
| [1] Patke A, Young M W, Axelrod S. Molecular mechanisms and physiological importance of circadian rhythms. Nat Rev Mol Cell Biol, 2020,21(2):67-84. [2] Joshi A, Upadhyay K K, Vohra A, et al. Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease. FASEB J,2021,35(9):e21803. [3] Tahara Y, Shibata S. Chrono-biology, chrono-pharmacology, and chrono-nutrition. J Pharmacol Sci, 2014,124(3):320-335. [4] Eslam M, Sanyal A J, George J. MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease. Gastroenterology, 2020,158(7):1999-2014. [5] Gnocchi D, Custodero C, Sabba C, et al. Circadian rhythms: a possible new player in non-alcoholic fatty liver disease pathophysiology. J Mol Med (Berl), 2019,97(6):741-759. [6] Pilorz V, Helfrich-Forster C, Oster H. The role of the circadian clock system in physiology. Pflugers Arch, 2018,470(2):227-239. [7] Sprenger R R, Hermansson M, Neess D, et al. Lipid molecular timeline profiling reveals diurnal crosstalk between the liver and circulation. Cell Rep, 2021,34(5):108710. [8] Held N M, Wefers J, van Weeghel M, et al. Skeletal muscle in healthy humans exhibits a day-night rhythm in lipid metabolism. Mol Metab, 2020,37:100989. [9] Dyar K A, Lutter D, Artati A, et al. Atlas of circadian metabolism reveals system-wide coordination and communication between clocks. Cell, 2018,174(6):1571-1585. [10] Lange M, Angelidou G, Ni Z, et al. AdipoAtlas: A reference lipidome for human white adipose tissue. Cell Rep Med, 2021,2(10):100407. [11] Li J, Vungarala S, Somers V K, et al. Rest-activity rhythm is associated with obesity phenotypes: A cross-sectional analysis. Front Endocrinol (Lausanne), 2022,13:907360. [12] Petrenko V, Sinturel F, Riezman H, et al. Lipid metabolism around the body clocks. Prog Lipid Res, 2023,91:101235. [13] Chen Y, Chen X, Gao J, et al. Long noncoding RNA FLRL2 alleviated nonalcoholic fatty liver disease through Arntl-Sirt1 pathway. FASEB J, 2019,33(10):11411-11419. [14] Cohen J C, Horton J D, Hobbs H H. Human fatty liver disease: old questions and new insights. Science, 2011,332(6037):1519-1523. [15] Fabbrini E, Mohammed B S, Magkos F, et al. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology, 2008,134(2):424-431. [16] Ray S, Valekunja U K, Stangherlin A, et al. Circadian rhythms in the absence of the clock gene Bmal1. Science, 2020,367(6479):800-806. [17] Ehlen J C, Brager A J, Baggs J, et al. Bmal1 function in skeletal muscle regulates sleep. Elife, 2017,6. [18] Welz P S, Benitah S A. Molecular connections between circadian clocks and aging. J Mol Biol, 2020,432(12):3661-3679. [19] Viebahn G, Hartmann P, Lang S, et al. Fungal signature differentiates alcohol-associated liver disease from nonalcoholic fatty liver disease. Gut Microbes, 2024,16(1):2307586. [20] Xu L, Yang T Y, Zhou Y W, et al. Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/alpha-KG-mediated glycolysis. Acta Pharmacol Sin, 2022,43(2):316-329. [21] Jokl E, Llewellyn J, Simpson K, et al. Circadian disruption primes myofibroblasts for accelerated activation as a mechanism underpinning fibrotic progression in non-alcoholic fatty liver disease. Cells, 2023,12(12):612-618. [22] Shen X, Zhang Y, Ji X, et al. Long noncoding RNA lncRHL regulates hepatic VLDL secretion by modulating hnRNPU/BMAL1/MTTP axis. Diabetes, 2022,71(9):1915-1928. [23] Chen Y, Chen X, Gao J, et al. Long noncoding RNA FLRL2 alleviated nonalcoholic fatty liver disease through Arntl-Sirt1 pathway. FASEB J, 2019,33(10):11411-11419. [24] Aggarwal S, Rastogi A, Maiwall R, et al. Palmitic acid causes hepatocyte inflammation by suppressing the BMAL1-NAD(+)-SIRT2 axis. J Physiol Biochem, 2024. [25] Jouffe C, Weger B D, Martin E, et al. Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease. Proc Natl Acad Sci U S A, 2022,119(10):e2094884177. [26] Rada P, Gonzalez-Rodriguez A, Garcia-Monzon C, et al. Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver? Cell Death Dis, 2020,11(9):802. [27] Zhan C, Chen H, Zhang Z, et al. BMAL1 deletion protects against obesity and non-alcoholic fatty liver disease induced by a high-fat diet. Int J Obes (Lond), 2024,48(4):469-476. [28] Liu C, Zhou B, Meng M, et al. FOXA3 induction under endoplasmic reticulum stress contributes to non-alcoholic fatty liver disease. J Hepatol, 2021,75(1):150-162. [29] Larion S, Padgett C A, Butcher J T, et al. The biological clock enhancer nobiletin ameliorates steatosis in genetically obese mice by restoring aberrant hepatic circadian rhythm. Am J Physiol Gastrointest Liver Physil, 2022,323(4):G387-G400. [30] Carbone A, De Santis E, Cela O, et al. The histone variant macroH2A1 impacts circadian gene expression and cell phenotype in an in vitro model of hepatocellular carcinoma. Biomedicines, 2021,9(8):312-316. [31] Larion S, Padgett C A, Butcher J T, et al. The biological clock enhancer nobiletin ameliorates steatosis in genetically obese mice by restoring aberrant hepatic circadian rhythm. Am J Physiol Gastrointest Liver Physiol, 2022,323(4):G387-G400. [32] Chou C F, Zhu X, Lin Y Y, et al. KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression. J Lipid Res, 2015,56(2):227-240. [33] Viebahn G, Hartmann P, Lang S, et al. Fungal signature differentiates alcohol-associated liver disease from nonalcoholic fatty liver disease. Gut Microbes, 2024,16(1):2307586. [34] Zhao D, Wang X, Liu H, et al. Effect of circadian rhythm change on gut microbiota and the development of nonalcoholic fatty liver disease in mice. Sleep Med, 2024,117:131-138. [35] Matenchuk B A, Mandhane P J, Kozyrskyj A L. Sleep, circadian rhythm, and gut microbiota. Sleep Med Rev, 2020,53:101340. [36] Song D, Ho C T, Zhang X, et al. Modulatory effect of Cyclocarya paliurus flavonoids on the intestinal microbiota and liver clock genes of circadian rhythm disorder mice model. Food Res Int, 2020,138(Pt A):109769. [37] Liang X, Bushman F D, FitzGerald G A. Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock. Proc Natl Acad Sci U S A, 2015,112(33):10479-10484. [38] Tosini G, Ferguson I, Tsubota K. Effects of blue light on the circadian system and eye physiology. Mol Vis, 2016,22:61-72. [39] Chen Y T, Huang P Y, Chai C Y, et al. Early detection of the initial stages of LED light-triggered non-alcoholic fatty liver disease by wax physisorption kinetics-Fourier transform infrared imaging. Analyst, 2023,148(3):643-653. [40] Shen X, Chen Y, Zhang J, et al. Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice. Environ Int, 2019,128:146-157. [41] Abraham A, Chakraborty P. A review on sources and health impacts of bisphenol A. Rev Environ Health, 2020,35(2):201-210. [42] Motta G, Thangaraj S V, Padmanabhan V. Developmental programming: Impact of prenatal exposure to bisphenol A on senescence and circadian mediators in the liver of sheep. Toxics, 2023,12(1):23-27. [43] Roy S, Abudu A, Salinas I, et al. Androgen-mediated perturbation of the hepatic circadian system through epigenetic modulation promotes NAFLD in PCOS mice. Endocrinology, 2022,163(10):723-728. [44] Zhao Y, Yan Y, Xie L, et al. Long-term environmental exposure to microcystins increases the risk of nonalcoholic fatty liver disease in humans: A combined fisher-based investigation and murine model study. Environ Int, 2020,138:105648. [45] Park H, Lee S J. Working hours and nonalcoholic fatty liver disease according to sleep duration. Chronobiol Int, 2019,36(12):1671-1680. [46] Vetrani C, Barrea L, Verde L, et al. Evening chronotype is associated with severe NAFLD in obesity. Int J Obes (Lond), 2022,46(9):1638-1643. [47] Ruiz-Lozano T, Vidal J, de Hollanda A, et al. Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C. Int J Obes (Lond), 2016,40(10):1550-1557. [48] Lotti S, Pagliai G, Colombini B, et al. Chronotype differences in energy intake, cardiometabolic risk parameters, cancer, and depression: A systematic review with Meta-analysis of observational studies. Adv Nutr, 2022,13(1):269-281. [49] Castelnuovo G, Perez-Diaz-Del-Campo N, Rosso C, et al. Impact of chronotype and Mediterranean diet on the risk of liver fibrosis in patients with non-alcoholic fatty liver disease. Nutrients, 2023,15(14):1126-1129. [50] Bernsmeier C, Weisskopf D M, Pflueger M O, et al. Sleep disruption and daytime sleepiness correlating with disease severity and insulin resistance in non-alcoholic fatty liver disease: A comparison with healthy controls. PLoS One, 2015,10(11):e143293. [51] Akram S T, Ewy M W, Said A. Sleep disruption in nonalcoholic fatty liver disease: What is the role of lifestyle and diet? Eur J Gastroenterol Hepatol, 2021,33(1S Suppl 1):e308-e312. [52] Gu W, Han T, Sun C. Association of 24 h behavior rhythm with non-alcoholic fatty liver disease among American adults with overweight/obesity. Nutrients, 2023,15(9):738-743. [53] Nassir F, Ibdah J A. Sirtuins and nonalcoholic fatty liver disease. World J Gastroenterol, 2016,22(46):10084-10092. [54] Yang Z, Kim H, Ali A, et al. Interaction between stress responses and circadian metabolism in metabolic disease. Liver Res, 2017,1(3):156-162. [55] Panda S. Circadian physiology of metabolism. Science, 2016,354(6315):1008-1015. [56] Ribas-Aulinas F, Ribo S, Parra-Vargas M, et al. Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD. Mol Metab, 2021,45(1)5-7. [57] Xia J, Guo W, Hu M, et al. Resynchronized rhythmic oscillations of gut microbiota drive time-restricted feeding induced nonalcoholic steatohepatitis alleviation. Gut Microbes, 2023,15(1):2221450. [58] Zeb F, Osaili T, Obaid R S, et al. Gut Microbiota and time-restricted feeding/eating: A targeted biomarker and approach in precision nutrition. Nutrients, 2023,15(2):125-128. [59] Heo N J, Park H E, Yoon J W, et al. The association between vitamin D and nonalcoholic fatty liver disease assessed by controlled attenuation parameter. J Clin Med, 2021,10(12):812-816. [60] Liu Y, Li Q, Wang H, et al. Fish oil alleviates circadian bile composition dysregulation in male mice with NAFLD. J Nutr Biochem, 2019,69:53-62. [61] Shang T, Liu L, Zhou J, et al. Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice. Lipids Health Dis, 2017,16(1):65. [62] Parker H M, Cohn J S, O'Connor H T, et al. Effect of fish oil supplementation on hepatic and visceral fat in overweight men: A randomized controlled trial. Nutrients, 2019,11(2):141-145. [63] Malhotra S, Sawhney G, Pandhi P. The therapeutic potential of melatonin: a review of the science. Med Gen Med, 2004,6(2):46. [64] Vasey C, McBride J, Penta K. Circadian rhythm dysregulation and restoration: The role of melatonin. Nutrients, 2021,13(10):812-815. [65] Hong F, Pan S, Xu P, et al. Melatonin orchestrates lipid homeostasis through the hepatointestinal circadian clock and microbiota during constant light exposure. Cells, 2020,9(2):165-169. [66] Sohrabi M, Gholami A, Amirkalali B, et al. Is melatonin associated with pro-inflammatory cytokine activity and liver fibrosis in non-alcoholic fatty liver disease (NAFLD) patients? Gastroenterol Hepatol Bed Bench, 2021,14(3):229-236. [67] Guan Q, Wang Z, Hu K, et al. Melatonin ameliorates hepatic ferroptosis in NAFLD by inhibiting ER stress via the MT2/cAMP/PKA/IRE1 signaling pathway. Int J Biol Sci, 2023,19(12):3937-3950. [68] Saha M, Das S, Manna K, et al. Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model. Biosci Rep, 2023,43(10):913-917. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||
