Abstract: Objective This study was conducted to investigate double endoscopic surgery in the treatment of patients with gallbladder stones (GS) and extrahepatic bile duct stones (EBDS). Methods 76 patients with GS and EBDS were encountered in our hospital between January 2020 and December 2022, 42 patients in the observation group received laparoscopic cholecystectomy (LC) five days after endoscopic retrograde cholangiopancreatography (ERCP) for the removal of common bile duct stones, and 34 patients in the control underwent traditional open surgery. The pain was evaluated by visual analogue scale (VAS), and serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP) and cortisol (Cor) levels were detected by ELISA. The white blood cell counts (WBC) were detected by full-automatic blood cell analyzer. Results The stone clearance rates in the two groups were both 100.0%; the operation time, intraoperative blood loss and VAS score at day 3 after surgery in the observation were(96.8±7.4)min,(25.7±5.3)ml and (2.8±0.7), significantly shorter or less than [(120.1±9.6)min, (46.0±6.8)ml and (3.5±0.6), respectively, P＜0.05] in the control; seven days after operation, serum AST and ALT levels were (40.5±3.9)U/L and (43.1±4.9)U/L, both significantly lower than [(50.2±5.0)U/L and (56.9±6.0)U/L, P＜0.05] in the control; serum TNF-α, IL-6, CRP, Cor levels and WBC counts were (1.5±0.3)ng/L, (10.8±2.0)ng/L, (13.4±2.5)mg/L, (224.7±28.1)mmol/L and (9.8±1.3)×10⁹/L, all significantly lower than [(2.7±0.5)ng/L, (16.1±2.5)ng/L, (22.0±4.9)mg/L, (262.4±31.8)mmol/L and (12.0±1.5)×10⁹/L, respectively, P＜0.05] in the control; post-operationally, the incidence of complications in the observation group was 7.2%, much lower than 23.5%(P＜0.05) in the control. Conclusion The double endoscopic surgery could effectively improve perioperative indexes, promote postoperative recovery, relieve stress response and reduce the complications in patients with GS and EBDS.

Key words: Gallstone stone, Extrahepatic bile duct stone, Endoscopic retrograde cholangiopancreatography, Laparoscopic cholecystectomy, Treatment