Journal of Practical Hepatology ›› 2023, Vol. 26 ›› Issue (6): 875-878.doi: 10.3969/j.issn.1672-5069.2023.06.027

• Liver cirrhosis • Previous Articles     Next Articles

Risk factors of re-bleeding in patients with hepatitis B cirrhosis and esophagogastric varices bleeding within one year after gastroscopic sclerotherapy and tissue glue injection

Yang Fan, Zhang Xiaojuan, Li Dan, et al   

  1. Department of Gastroenterology, Second People's Hospital, Jiangyou 621700, Sichuan Province, China
  • Received:2023-02-10 Online:2023-11-10 Published:2023-11-20

Abstract: Objective The aim of this study was to investigate the risk factors of re-bleeding in hepatitis B viral infection-induced liver cirrhosis (LC) complicated with esophagogastric varices bleeding (EGVB) within 1 year after gastroscopic sclerotherapy and tissue glue injection therapy. Methods A total of 137 patients with hepatitis B LC and EGVB were enrolled in our hospital between June 2016 and March 2021, and all patients underwent gastroscopic sclerotherapy and tissue glue injection therapy. They were all followed-up for 1 year to observe the occurrence of postoperative re-bleeding. The risk factors of re-bleeding were analyzed by multivariate Logistic regression analysis. Results Among the 137 patients with cirrhosis and EGVB, 28 patients (20.4%) died of emergent bleeding; out of the 109 survivals within 1 year of follow-up, the postoperative re-bleeding occurred in 42 cases (30.7%); there were significant differences between patients with re-bleeding and without re-bleeding as respect to Child-Pugh class (P=0.001), severity of esophageal varices (P=0.027), ascites volume (P=0.016) and malnutrition (P=0.009, P<0.05); the Logistic regression analysis showed that poor Child-Pugh class (OR=1.863), severe esophageal varices (OR=2.028), large volume of ascites (OR=1.797) and moderate to severe malnutrition (OR=1.589) were the independent risk factors for re-bleeding within 1 year after endoscopic therapy. Conclusion The patients with hepatitis B LC and EGVB after gastroscopic therapy could have high risk for re-bleeding within one year, and the careful intervention to these risk factors might decrease the incidence of re-bleeding and increase the survival rates of them.

Key words: Liver cirrhosis, Esophagogastric varices bleeding, Sclerotherapy, Tissue glue injection, Re-bleeding, Risk factors