Abstract: Objective The purpose of this study was to collect and summarize the clinical feature of patients with drug-induced liver injury (DILI), and to analyze the suspected medicines, clinical characteristics and clinical outcome of patients with DILI. Methods 60 patients with DILI were encountered in our hospital between August 2018 and December 2021,and we collect the clinical materials, including the suspected medicines, episode times, disease severities and treatment periods. The clinical categories and disease grades were determined. The outcomes included recovery, with clinical symptoms and signs disappeared and liver function tests back to normal, and non-recovery. Results The main medicines in the 60 patients with DILI were chemical medicines in 16 cases(26.7%), Chinese herbal medicine in 13 cases(21.7%), antibiotics in 8 cases(13.3%), antithyroid medicines in 7 cases(11.7%), hypolipidemic drugs in 5 cases (8.3%), anti-tuberculosis drugs in 4 cases (6.7%), psychotropic drugs in 3 cases (5.0%), antihypertensive drugs in 2 cases (3.3%) and health products in 2 cases (3.3%); the episode time ranged from 2 to 118 days, and within one week in 19 cases (31.7%), one week to three months in 24 cases (40.0%) and longer than three months in 17 cases(28.3%); the clinical manifestations included anorexia in 13 cases (21.7%), nausea and vomiting in 13 cases (21.7%), fatigue in 12 cases (20.0%), jaundice in 13 cases (21.7%), abdominal pain and diarrhea in 8 cases (13.3%), pruritus in 2 cases (11.7%), and without obvious symptoms in 25 cases (41.7%); the disease severities included grade one in 42 cases (70.0%), grade two in 7 cases(11.7%), grade three in 6 cases (10.0%) and grade four in 5 cases (8.3%), without grade five in our series; the ages and gender between 49 patients with ≤grade 2 and 11 patients with ≥ grade 3 were not significantly different (P>0.05), while the episode time in patients with ≥grade 3 were shorter and the hospitalization stay longer (P<0.05); 54 patients recovered and 6 patients didn’t in our series. Conclusion The most common clinical symptoms in our patients with DILI are digestive system-related, and the common medicines which lead to DILI include chemical medicines, Chinese herbal medicines, antibiotics, antithyroid drugs, hypolipidemic drugs and so on. The patients with poor clinical outcome tend to have severe liver function injuries with coagulation function tests deteriorated, and need careful management in clinical practice.

Key words: Drug-induced liver injury, Chinese herbal medicine, Liver function grades, Prognosis