Abstract: Objective To investigate the dynamic changes of serum anti-HEV IgM, IgG and HEV RNA in patients with acute hepatitis E (AHE). Methord Serum anti-HEV IgM, IgG and HEV RNA loads were detected in a consecutive 217 patient with AHE, who were admitted to our Hospital between January 2016 and March 2018. Results At presentation,serum anti-HEV IgM, anti-HEV IgG and HEV RNA positive in 31 cases(14.3%), anti-HEV IgM and IgG positive in 99 cases (45.5%), anti-HEV IgM positive in 8 cases (3.7%), anti-HEV IgG positive in 72 cases (33.2%), anti-HEV IgM and HEV RNA positive in 3 cases (1.5%), anti-HEV IgG and HEV RNA positive in 2 cases (0.9%), and anti-HEV IgM, IgG and HEV RNA negative in 2 cases(0.9%); in 75 patients with second detection, the results showed that serum anti-HEV IgG positive increased; in 138 patients with accurate onset of the disease, serum HEV RNA positive at week one, two, three, four and after four were 49.0%(25/51), 10.2%(6/59), 3.1%(1/32), 4.0%(1/25) and 0.0%(0/0); serum anti-HEV IgM positive were 70.6%(36/51), 69.5%(41/59), 65.6%(21/32), 48%(12/25) and 56.5%(13/23); serum anti-HEV IgG positive were 90.2%(46/51), 88.1%(52/59), 96.9%(31/32), 100%(25/25) and 100.0%(23/23). Conclusion Serum anti-HEV IgM, IgG and HEV RNA changes regularly in patients with AHE, which might help clinicians to make decisions for diagnosis and management.

Key words: Hepatitis E, Anti-HEV IgM, Anti-HEV IgG, HEV RNA