Abstract: Objective The purpose of this study was to explore the diagnostic value of serological indexes and fatty liver index (FLI) in patients with nonalcoholic fatty liver diseases (NAFLD). Methods 86 patients with NAFLD and 86 healthy persons were recruited in our Department between March 2016 to March 2019, and serum pancreatic lipase (P-LIP), procalcitonin (PCT), C-reactive protein (CRP) were assayed, and fatty liver index (FLI) was calculated. Results Serum PCT and CRP levels as well as FLI in patients were (0.10±0.05) μg/L,(5.6±1.0)μg/L and (37.4±3.6), significantly higher than 【(0.04±0.02)μg/L,(2.8±0.7)μg/L and (18.2±1.3), respectively, P<0.05】, while serum P-LIP level was (27.1±2.4)U/L, much lower than 【(35.8±3.2)U/L, P<0.05】 in healthy individuals; serum PCT, CRP, P-LIP and FLI in 18 patients with non-alcoholic steatohepatitis (NASH)-related cirrhosis were (0.18±0.07)μg/L, (7.4±1.2)μg/L, (22.9±1.7)U/L and 39.41±4.0, significantly different as compared to 【(0.11±0.04)μg/L, (4.8±0.5)μg/L, (27.7±2.2)U/L and (38.0±3.7), respectively, in 33 patients with NASH or 【(0.07±0.02)μg/L, (3.0±0.3)μg/L, (34.2±2.6)U/L and (35.8±3.4), respectively, in 35 patients with single non-alcoholic fatty liver(P<0.05); the sensitivity (Se) and specificity (Sp) of FLI in diagnosing NAFLD were 76.7% and 73.3%, while they were 66.3% and 86.1% when combination of FLI with serumCRP, PCT and P-LIP. Conclusion The application of FLI is a simple way to diagnose patients with NAFLD , and the combination of serum index might improve the diagnostic efficiency.

Key words: Non-alcoholic fatty liver disease, Fatty liver index, Procalcitonin, Pancreatic lipase, Diagnosis