Abstract: Objective The aim of this stud was to investigate the changes and its clinical significance of serum lipids,liver function index and estrogen levels in patients with intrahepatic cholestasis of pregnancy （ICP）. Methods The clinical data of 120 patients with ICP who were admitted in our hospital between March 2014 and September 2018 were analyzed. According to the severity of ICP,there were 81 patients with mild and 39 patients with severe ICP. Another 50 healthy pregnant women in the same period were selected as the control group. Serum estradiol,estratriol and total bile acid（TBA） levels were detected by RIA. Results Blood triglyceride （TG）,total cholesterol （CHOL） and low density lipoprotein （LDL） levels in patients with severe ICP were （4.9±0.8） mmol/L,（7.9±1.0） mmol/L and （4.1±1.3） mmol/L,significantly higher than （3.3±0.7） mmol/L,（5.7±0.8） mmol/L and （3.2±0.7） mmol/L in patients with mild ICP or [（2.3±0.5） mmol/L,（4.5±0.6） mmol/L and （2.1±0.5） mmol/L,P<0.05] in healthy women （P<0.05）;serum aspartate aminotransferase （AST）,alanine aminotransferase and TBA levels in patients with severe ICP were（93.2±43.5） U/L,（87.7±52.3） U/L and（65.3±37.5） μmol/L,significantly higher than （38.3±7.4） U/L,（41.4±6.5） U/L and（8.9±5.2） μmol/L in healthy individuals or [（43.4±11.6） U/L,（39.3±11.5） U/L and（15.2±6.5） μmol/L,respectively,P<0.05] in patients with mild ICP;serum estradiol and estratriol levels in patients with severe ICP were （83.6±13.5） ng/L and （47.82±20.19） ng/L,significantly higher than （67.2±11.4） ng/L and （39.2±15.4） ng/L in patients with mild ICP or [（43.2±7.5） ng/L and （23.3±12.6） ng/L,P<0.05] in the control;the incidences of preterm delivery,neonatal asphyxia and intrauterine distress in patients with severe ICP were 18.0%,12.8% and 12.8%,much higher than 11.1%,8.6% and 9.9% in patients with mild ICP or 2.0%,0.0% and 2.0% in the control（P<0.05）. Conclusion The blood lipids,liver function tests and estrogen levels in patients with ICP changes greatly,which might help evaluate the severity of ICP and guide clinical managements.

Key words: Intrahepatic cholestasis of pregnancy, Blood lipids, Estrogen