Abstract: Objective To investigate the awareness of antiviral treatment in patients with hepatitis B virus （HBV）-related liver cirrhosis and the content of chronic hepatitis B prevention and treatment guidelines（2010, China）in gastroenterologist from tertiary hospitals in Chengdu. Methods Questionnaire based on newly published chronic hepatitis B prevention and treatment guidelines were designed and a total of 224 gastroenterologists in 20 tertiary general hospitals in Chengdu completed the questionnaires on the principle of volunteer,anonymity and independence. The questionnaires were collected by special investigators from our team. Results 208（92.9%） respondents acquired the treatment-related acknowledge mainly by reading the updated guidelines. The necessity and course of anti-HBV regimen were well known,with 220 respondents（98.2%） knowing the antiviral treatment necessary to patients with HBV-related cirrhosis,but 203（90.63%） unaware of the course of treatment. However,the respondents were relatively poor understanding of the antiviral indications,treatment process and follow-up. Only 40（17.9%） respondents gave the correct answer of antiviral indications in HBeAg-positive patients in compensated stage;35（15.6%） gave the correct answer of antiviral indications in HBeAg-negative patients in compensated stage; 87（38.8%） gave the correct answer of antiviral indications in patients with decompensated HBV-related cirrhosis; only 28（12.5%） knew the requirement of follow-up in patients with stable condition after treatment. According to the survey of this study,adefovir dipivoxil,one of nucleoside analogues,was best known, by 193（86.2%） respondents,and 161（71.9%） respondents believed that the costs of the medicine was the major factor determining the choice of antiviral medication. Conclusion Gastroenterologists in tertiary general hospitals in Chengdu have a good understanding of the purpose and necessity of antiviral treatment in patients with HBV-related liver cirrhosis,but have a relatively poor acknowledge about the antiviral indications, choices of antiviral agents, and requirements of follow-up.

Key words: Liver cirrhosis, Hepatitis B, Nucleoside analogues, Gastroenterologist, Guideline