肿瘤患者血清线粒体肌酸激酶水平变化及其诊断意义研究进展*

doi:10.3969/j.issn.1672-5069.2015.02.033

Abstract

Abstract: Mitochondrial creatine kinase（MtCK） located in the space between inner membrance and outer membrance of intracellular mitochondria. Creatine kinase is a member of the creatine kinase isozyme. The mainly physiological function of MtCK is to provide the energy for muscle contraction through the creatine phosphate shuttle mechanism under aerobic condition， which plays an important role in mitochondrial respiratory control. Recently，over expression of ubiquitous MtCK（uMtCK） is found in malignant tumors with especially poor prognosis. The molecular biology mechanism of the over expression in malignant tumors is well studied and the scholars find that uMtCK might be useful in the diagnosis of malignant tumors. Meanwhile，molecular biology studies shows that over expression of uMtCK promotes malignant tumors growth though resisting apoptosis. We reviewed the role and molecular biologic mechanism of mitochondrial creatine kinase in the diagnosis of malignant tumor.

Key words: Neoplasma, Mitochondrial creatine kinase, Clinical diagnosis

Zhang Ningning，Lu Wei. Serum mitochondrial creatine kinase levels in the diagnosis of patients with malignant tumor[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2015, 18(4): 445-448.

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Serum mitochondrial creatine kinase levels in the diagnosis of patients with malignant tumor

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