Abstract: Objective To explore the application of multimodal analgesia under the idea of enhanced recovery after surgery in laparoscopic cholecystectomy（LC）. Methods 120 patients with gall stone（n=82） or gallbladder polyp（n=38） were recruited and divided randomly into routine analgesia （control group） and multimodal analgesia under the fast track surgery（study group）,with 60 cases in each group. The perioperative related indicators（postoperative duration of initial exhaust,duration of initial defecation, time of resumed eating,time of off-bed activities,total length of hospital stay） were compared between the two groups,and the pain scores was evaluated by Houston pain outcome instrument（HPOI） and the quality of life score by Pittsburgh sleep quality index（PSQI）. The incidence of postoperative complications was analyzed. Results The initial exhaust time,the initial defecation time,the time for feeding recovery,the ambulation time and the total hospital stay in the study group were（15.3±2.9） h,（30.6±4.3） h,（6.8±2.1） h,（4.8±1.4） h,（3.3±1.2） d,significantly shorter than [（19.2±3.1） h,（45.2±5.3） h,（9.2±2.4） h,（7.2±1.6） h,（4.8±1.4） d] in the control（P<0.05）;at 12 h,24 h and 72 h after operation,the scores of pain in study group were （6.3±1.6）,（7.6±2.1） and （8.3±2.4）,significantly higher than [（4.4±1.3）,（5.2±2.0） and （6.5±2.1）] in the control （P<0.05）,while the PSQI scores were （15.8±3.2）,（13.4±2.8）,（10.6±1.9）,significantly lower than [（18.6±3.5）,（17.5±3.2）,（15.8±2.8）] in the control （P<0.05）;there was no significant difference between the two groups as respect to the incidence rates of postoperative urinary retention,incision infection and deep venous thrombosis（3.3%,1.7%,6.7% vs. 5.0%,1.7%,10.0%,respectively,P>0.05）. Conclusion The application of multimodal analgesia under the idea of enhanced recovery after surgery in the treatment of patients with gall stone or gallbladder polyp after LC is of importance in relieving postoperative pain,improving sleep quality,and promoting the recovery.

Key words: Gallbladder stone, Gallbladder polyp, Laparoscopic cholecystectomy, Enhanced recovery after surgery, Multimodal analgesia