Abstract: Objective To investigate the changes of emotion,attitude and quality of life in patients with chronic hepatitis B（CHB）. Methods 75 patients with CHB and 70 healthy persons were recruited in our hospital between June 2015 and December 2016. The self rating anxiety scale（SAS）,self rating depression scale （SDS） and trait coping style questionnaire（TCSQ） and quality of life scale by WHO（WHOQOL-BREF） were obtained in the two groups. Logistic analysis was applied to evaluate the impact of them on the quality of life in patients with CHB. Results The SAS score,SDS score and the negative score of TCSQ in patients with CHB were （66.8±9.5）,（64.5±10.2） and （38.3±9.6）,respectively,much higher than [（37.9±8.4）,（41.3±9.1） and （23.1±6.4）,P<0.05] in the control;the positive score of TCSQ in patients with CHB was （26.4±8.1）,and HOQOL-BREF score was （65.7±14.3）,much lower than [（23.1±6.4） and （78.4±8.2）,P<0.05] in the control; the physical and psychological score of WHOQOL-BREF in patients with CHB were positively correlated to positive score and negative score of SAS,SDS and TCSQ（P<0.05 or P<0.01）,and Logistic analysis showed than the SDS,PC and NC score were the factors influencing the quality of life in patients with CHB（P<0.01）. Conclusions The quality of life in patients with CHB is relatively decreased, especially in physiological and psychological fields, which warrants social and clinical concerns.

Key words: Chronic hepatitis, Emotion, Attitude, Quality of life