Abstract: Objective This study aimed to explore qualitative judgement of focal liver lesions (FLL) by quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Methods 107 patients with FLL were encountered in our hospital between January 2022 and January 2025, and all patients underwent DCE-MRI examination to record initial area under enhancement curve (IAUC), maximum slope of increase (MSI), maximum slope of decrease (MSD), mean enhancement time (MET) and positive enhancement integral (PEI). Golden diagnosis was proven by histo-pathological examination. Receiver operating characteristic (ROC) curves was applied to validate the diagnostic efficacy. Results Of the 107 patients with FLL in our series, pathological exam found benign lesions in 37 cases, hepatocellular carcinoma (HCC) in 56 cases and intrahepatic cholangiocarcinoma (ICC) in 9 cases; IAUC and MSD in benign lesions were (21.5±3.5) and (83.2±9.5), both much smaller than(P＜0.05), while MSI, MET and PEI were (283.2±26.6), (552.4±68.6) and (249.9±24.5), all much greater than in malignant lesions (P＜0.05); MSI, MET and PEI in HCC foci were (93.3±11.3), (486.5±61.4) and (32.5±6.6), all significantly smaller than [(103.3±10.3), (515.4±51.3) and (41.5±7.8), respectively, P＜0.05] in ICC foci; the AUC was 0.906, when IAUC, MSI, MSD, MET and PEI were combined to predict malignant lesions, and the AUC was 0.856, when MSI, MET and PEI were combined to differentiate HCC from ICC, both had to some extent implications of clinical practice. Conclusion DCE-MRI quantitative parameters could help clinicians differentiate base on imaging benign from malignant intrahepatic lesions, which warrants further clinical investigation.

Key words: Hepatoma, Intrahepatic cholangiocarcinoma, Focal liver lesions, Dynamic contrast-enhanced magnetic resonance imaging, Diagnosis