Abstract: Objective The aim of this study was to investigate multimodal nalbuphine hydrochloride analgesia in patients with gallbladder polyps (GP) after laparoscopic cholecystectomy(LC). Methods 78 patients with GP were encountered in our hospital between November 2020 and March 2024, and all underwent LC surgery. For post-operational analgesia, patients were randomly divided into control and observation groups, 39 cases in each. Bilateral transversus abdominis plane block (TAP) and patient-controlled intravenous analgesia (PCIA) were conducted, nalbuphine were given in observation, and flurbiprofen ester were administered in the control. Visual analogue scale (VAS) and Ramsay sedation scale (RSS) were evaluated, and serum substance P (SP) and prostaglandin E2 (PGE2) levels were assayed by RIA. Results By 1, 4 and 12 hours after surgery, VAS scores in the observation group were(3.7±0.7)points, (4.0±0.8)points and (4.3±0.9)points, all much lower than [(4.3±0.7)points, (4.6±0.9)points and (4.9±1.0)points, P＜0.05] in the control; by 1, 4, 12 and 24 hours, RSS scores were (2.4±0.5)points, (2.6±0.6)points, (2.9±0.6)points and (2.5±0.6)points, all not significantly different compared to [(2.5±0.6)points, (2.7±0.6)points, (3.0±0.7)points and (2.6±0.5)points, P>0.05]; by 1, 4 and 12 hours, serum SP levels were (0.9±0.2)μg/mL, (2.7±0.6)μg/mL and (4.3±1.0)μg/mL, all much lower than [(1.3±0.3)μg/mL, (4.4±1.1)μg/mL and (6.5±1.3)μg/mL, respectively, P＜0.05], and serum PEG2 levels were (91.9±11.5)pg/mL, (265.3±29.6)pg/mL and (168.3±18.7)pg/mL, all much lower than [(108.8±12.7)pg/mL, (304.2±32.8)pg/mL and (183.2±20.6)pg/mL, respectively, P＜0.05] in the control group; post-operationally, first exhaust time, food intake and removal of drainage tube in the observation were(40.7±4.2)h, (41.6±3.9)h and (90.6±8.4)h, all much shorter than [(49.8±5.3)h, (50.4±21.5)h and (103.7±4.1)h, respectively, P＜0.05] in the control. Conclusion Application of nalbuphine hydrochloride in multimodal analgesia after LC is beneficial to relieve pain, which might be related to inhibition of pain-related substance release.

Key words: Gallbladder polyps, Laparoscopic cholecystectomy, Bilateral transversus abdominis plane block, Patient-controlled intravenous analgesia, Nalbuphine hydrochloride, Analgesia