Abstract: Objective The aim of this study was to investigate the effect of radical treatment of Helicobacter pylori (Hp) on serum inflammatory factors and lipid metabolism in patients with Hp-positive nonalcoholic fatty liver disease (NAFLD). Methods 168 patients with Hp-positive NAFLD were enrolled to our hospital between June 2015 and June 2019, and were divided randomly into two groups, with 84 cases in each. The patients in control group received polyene phosphatidylcholine and metformin, while those in the observation group received standardized therapy for Hp eradication at the base of treatments in the control. Serum levels of tumor necrosis factor-alpha (TNF-alpha), hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and IL-8 were assayed, and fasting blood glucose (FPG), fasting insulin (FINS) and insulin resistance index (HOMA-IR) were also detected. Results At the end of one month after radical therapy, the eradication rate of Hp in the observation group was 94.0%, while no negative cases of Hp was found in the control (P<0.05); serum TNF-alpha in the observation group was (12.6±2.5) ng/L, significantly lower than , hs-CRP was (7.5±1.4) mg/L, significantly lower than , IL-6 was (12.5±2.3) ng/L, significantly lower than and serum IL-8 was (80.4±23.7) ng/L, significantly lower than in the control; blood total cholesterol level in the observation group was (3.1±0.9) mmol/L, significantly lower than , blood triglyceride was (1.5±0.8) mmol/L, significantly lower than , blood low density lipoprotein cholesterol was (0.9 ±0.4) mmol/L, significantly lower than , while blood high density lipoprotein cholesterol level was (2.4±0.3)mmol/L, significantly higher than【(1.8±0.4)mmol/L, P＜0.05】 in the control; serum FINS level in the observation group was (16.0±5.2) uIU/ml, significantly lower than , and HOMA-IR was (3.9±2.4), significantly lower than in the control. Conclusion Radical treatment of Hp might play an important role in reducing blood inflammatory factors, correcting the disorder of glycolipid metabolism and improving liver functions in Hp-positive NAFLD patients.

Key words: Nonalcoholic fatty liver diseases, Helicobacter pylori infection, Inflammatory factors, Lipid metabolism, Radical treatment