Abstract: Objective To investigate the efficacy of peginterferon alfa-2b treatment and affecting response factors in patients with chronic hepatitis B （CHB）.Methods A total of 105 patients with CHB were recruited in our hospital between June 2015 and December 2017,and all patients were treated by peginterferon alfa-2b for 48 weeks. Serum HBV DNA,HBeAg and HBsAg,as well as interferon-γ-induced protein-10（IP-10）,interferon-α/β receptor （IFNAR）,and T helper cell 17 （Th-17） were detected. Multivariate Logistic regression analysis was applied to demonstrate the prognostic factors of response to peginterferon alfa-2b therapy in patients with CHB.Results At the end of treatment regimen,56 patients（53.3%）,while 49 failed to respond to peginterferon alfa-2b therapy;there were no significant differences as respect to blood platelet counts,serum albumin,total bilirubin,prothrombin time,IFNAR-α and IFNAR-β between responders and non-responders（P>0.05）,while the baseline white blood cell counts,serum alanine aminotransferase,HBV DNA loads,HBsAg,IP-10,IL-17A and IL-17F in the responded group were（5.6±1.7）×10⁹/L,（108.6±9.5） U/L,（5.4±0.8） lg copies/ml,（4.6±0.9） lg IU/ml,（324.5±86.9） pg/ml,（3.2±0.6） mean fluorescene intendity （MFI） and（3.1±0.5） MFI in responders,significantly different as compared to（6.4±1.9）×10⁹/L,（82.5±10.0） U/L,（6.1±0.9） lgcopies/ml,（5.8±1.1） lg IU/ml,（381.4±79.6） pg/ml,（3.8±0.7） MFI and （3.6±0.7） MFI in the non-responder group （P<0.05）;multivariate Logistic regression analysis showed that serum HBV DNA loads,HBsAg,IP-10,IL-17A and IL-17F were the prognostic factors of response in patients with CHB treated with α-interferon （P<0.05）. Conclusion Serum HBV DNA,HBsAg,IP-10 and Th-17 are the prognostic factors affecting the response in patients with CHB after treatment of α-interferon,and detection of serum IP-10 and Th-17 might help predict the efficacy of peginterferon alfa-2b treatment.

Key words: Chronic hepatitis B, IFN-γ inducible protein 10, Interferon-α/β receptor, Th-17, Response, Prediction