Abstract: Objective To evaluate the short-term efficacy of gamma knife radiosurgery in the treatment of patients with malignant obstructive jaundice. Methods 20 patients with malignant obstructive jaundice were treated by gamma knife radiosurgery. According to the size and location of the tumors,different diameters of collimator helmets were used. The radiosurgery plan was designed to cover whole target area at isodose curves of 50% to 70% with a margin dose of 3 to 5 Gy each time and the total margin dose of 35 to 50Gy,which was carried out at a frequency of 3 to 5 times each week. Results The serum levels of total bilirubin decreased from 215.4±143.5μmol/L to 98.4±54.5μmol/L after two week treatment（P<0.01）;CR was in 3 and PR in 14 patients with the effective rate of 85%;The pain intensity measured by numerial rating scale was 6.96±1.21 before the treatment,while it was 2.06±1.07 after the treatment. Conclusion Gamma knife radiosurgery is an effective and safe treatment in patients with malignant obstructive jaundice.

Key words: Malignant obstructive jaundice, Neoplasm, Metastasis, Gamma knife/radiotherapy