Abstract: Objective To investigate the clinical and epidemiological characteristics of acute hepatitis B（AHB） in recent years. Methods To analyze the clinical data of 384 patients of AHB by using the software SPSS 13.0. Results This result indicated that the susceptible population of AHB was the patients with the age changing from 18 to 45. The main route of transmission remained unknown. The main nationality was Han. The morbidity of male was higher than that of female. The rate of recovery and improvement was 98.9%. The incidence of liver failure was 0.5%. Six months after onset,HBsAg in 97.1% cases and HBV DNA in 98.5% cases changed into negative. Conclusion The age of morbidity and the route of transmission have changed greatly. The rate of recovery and improvement is higher. Only few of the AHB patients converted to the chronic HB and severe hepatitis.

Key words: Acute hepatitis B, Clinical characteristics, Follow up