Abstract: Objective The aim of this study was to investigate the clinical efficacy of partial splenic embolization (PSE) based on highly selective catheterization of splenic artery in the treatment of patients with liver cirrhosis. Methods 96 patients with hepatitis B- or C-induced liver cirrhosis were encountered in our hospital between February 2023 and May 2025, and splenectomy and pericardial devascularization were conducted in 42 cases and PSE supported by highly selective catheterization of splenic artery was performed in another 54 cases. Portal vein diameter (PVD) and portal vein flow (PVF) were measured by Doppler ultrasonic diagnosis apparatus. Results By end of three-month after operation, platelet and red blood cell counts in PSE-treated patients were (108.6±32.4)×10⁹/L and (3.6±0.8)×10¹²/L,both much lower than [(126.9±28.7)×10⁹/L and (4.2±0.8)×10¹²/L,respectively, P<0.05] in splenectomy-treated patients; there were no significant differences as respect to liver function tests, PVD and PVF changes between the two groups (P>0.05); post-operationally, incidences of complications in PSE-treated patients was 16.7%,much lower than 33.3%(P<0.05) in splenectomy-treated patients,and portal thrombosis occurred in four cases (9.5%) in the latter group. Conclusion PSE based on highly selective catheterization of splenic artery in the treatment of patients with liver cirrhosis also oculd ameliorate hypersplenism to some intent, with less severe adverse effects and warrants further clinical investigation.

Key words: Liver cirrhosis, Hypersplenism, Partial splenic embolization, Highly selective catheterization, Therapy