Abstract: Objective The purpose of this study was to investigate prediction of concomitant nonalcoholic fatty liver disease (NAFLD) in patients with type two diabetes mellitus (T2DM) by visceral fat area (VFA) and blood lipid. Methods 52 patients with T2DM and concomitant NAFLD and 48 patients with T2DM were encountered in our hospital between June 2021 and June 2023, VFA was detected by Japanese made special visceral fat detection apparatus, and blood lipid and waist-to-hip ratio (WHR) were routinely determined. Multivariate Logistic regression analysis was applied to find impacting factors for NAFLD coexistence, and area under receiver operating characteristic curve (AUC) was used to verify predicting performance. Results BMI, VFA, WHR, serum triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels in patients with T2DM/NAFLD group were(26.4±3.1)kg/m²,(114.8±21.8)cm², (1.0±0.1), (2.9±1.1)mmol/L, (6.6±1.0)mmol/L and (4.2±0.9)mmol/L, all significantly higher than [(23.6±3.6)kg/m², (88.2±19.5)cm², (0.9±0.1), (1.6±0.8)mmol/L, (4.7±0.9)mmol/L and (2.8±0.8)mmol/L, respectively, P＜0.05], while serum high-density lipoprotein cholesterol (HDL-C) level was (0.9±0.5)mmol/L, significantly lower than [(1.2±0.3)mmol/L, P＜0.05] in T2DM group; multivariate Logistic regression analysis showed that BMI, VFA, WHR and serum TG, TC and LDL-C levels were all the independent risk factors for co-existence of NAFLD in patients with T2DM, and serum HDL-C level was the protective factor; ROC analysis demonstrated that combination of VFA, WHR and blood lipid were much superior to any parameter did in predicting co-existence of NAFLD, with sensitivity of 94.2% and specificity of 77.1%. Conclusion Combination of VFA, WHR and blood lipids in predicting concomitant NAFLD in patients with T2DM is efficacious, which might help clinicians make appropriately measures for further intervention.

Key words: Nonalcoholic fatty liver disease, Type 2 diabetes mellitus, Visceral fat area, Waist-to-hip ratio, Blood lipids, Diagnosis