Abstract: Objective The aim of this study was to investigate clinical efficacy of tenofovir amibufenamide (TMF) and Biejiajian compound, a herbal medicine pill, combination in the treatment of patients with chronic hepatitis B (CHB). Methods A total of154 naïve patients with CHB were enrolled in our hospital between August 2022 and July 2024, and were randomly assigned to receive TMF in 77 cases in the control group or to receive TMF and herbal medicine combination therapy in another 77 cases in the observation group. Serum HBV DNA loads was detected by real-time fluorescence quantitative PCR, serum HBsAg and HBeAg, precollagen type Ⅲ(PC-Ⅲ), collagen type IV(IV-Col), laminin (LN) and hyaluronic acid(HA), and interleukin(IL)-6,IL-8, tumor necrosis factor -ɑ(TNF-ɑ) and high-sensitive C reactive protein (hs-CRP) levels were measured by ELISA. Results By end of 48 week treatment, serum HBV DNA transferred to negative in all the patients with CHB in the two groups, and serum alanine aminotransferase level in the observation group was(42.4±7.4)IU/L, much lower than [(56.5±9.3)IU/L, P<0.05] in the control; serum PC-Ⅲ,HA and IV-Col levels were (112.5±18.3)μg/L, (132.5±17.9)μg/L and (159.7±11.8)μg/L, all significantly lower than [(157.3±21.3)μg/L, (162.9±20.2)μg/L and (197.5±29.2)μg/L, respectively, P<0.05] in the control; serum IL-6, IL-8 and TNF-ɑ levels were (6.3±1.1)pg/mL, (15.7±6.5)pg/mL and (20.5±9.5)pg/mL, all much lower than [(11.8±2.3)pg/mL,(28.1±9.1)pg/mL and (37.6±8.8)pg/mL, respectively, P<0.05] in the control group. Conclusion TMF and Biejiajian pill combination in the treatment of patients with CHB has a satisfactory efficacy, which might inhibit body inflammatory reaction and relieve liver fibrosis.

Key words: CHepatitis B, Tenofovir amibufenamide, Biejiajian pills, herbal medicine, Therapy