Abstract: Objective The aim of this study was to investigate ultrasonographic feature and qualitative diagnosis of intrahepatic solid space-occupying lesions (SSOL) by contrast-enhanced ultrasound (CEUS). Methods A total of 118 patients with intrahepatic SSOL were encountered in our hospital between March 2021 and March 2024, and all patients underwent CEUS check-up and hepatectomy. The consistency between CEUS and histopathological golden standard in qualitative diagnosis of benign and malignant lesions was analyzed by Kappa. The diagnostic efficacy of CEUS was analyzed by receiver operating characteristic (ROC) curves. Results Of 118 patients with intrahepatic SSOL, histopathological examination found malignant lesions in 72 cases and benign ones in 46 cases; in benign lesions, arrival time was (2.5±0.6)s, much shorter than [(3.6±0.8)s, P＜0.05], time to peak was (9.5±1.6)s, much longer than [(7.3±1.2)s, P＜0.05], peak intensity was (9.4±2.1)dB, much greater than [(5.8±0.9)dB, P＜0.05] and sharpness of fitted curve was (0.4±0.1)l/s, much less than [(1.2±0.3)l/s, P＜0.05] in malignant focci; there was a satisfactory consistency between CEUS and golden standard with a Kappa of 0.754(P＜0.05); the sensitivity, specificity, accuracy, positive predictive value and negative predictive value by CEUS were 87.5%, 89.1%, 88.1%, 92.7% and 82.0%, suggesting a good diagnostic efficacy (P＜0.05). Conclusion The qualitative diagnosis of intrahepatic SSOL by CEUS is efficacious, which might help clinicians make an appropriate measures to deal with as early as possible.

Key words: Intrahepatic solid space-occupying lesion, Contrast-enhanced ultrasound, Ultrasonographic feature, Diagnosis