Abstract: Objective The aim of this study was to observe the post-operational analgesia effects of dexmedetomidine (DEX) and butorphanol (BUT) combination in patients with primary liver cancer (PLC) after laparoscopic hepatectomy (LH). Methods 74 patients with PLC were enrolled in our hospital between January 2019 and October 20222, and were randomly divided into control (n=37) and observation group (n=37). All patients underwent selective LH, and post-operationally, the patients in the control and in the observation group were intravenously pumping in sufentanil (SUF) and BUT, and Dex and BUT combination for analgesia. The pain and sedation after surgery were evaluated by visual analogue scale (VAS) and Ramsay sedation. Results The operation times and anesthesia times between the observation and the control group were (210.4±20.2) min and (228.7±30.6) min vs. (208.1±28.3) min and (226.5±32.9) min (P>0.05), while the recovery of spontaneous breathing and awakening time in the observation group were(15.5±3.1) min and (18.2±4.3)min, both significantly shorter than [(20.3±4.9)min and (22.9±4.9)min, P＜0.05] in the control; at 4 h, 24 h and 48 h post-operationally, the VAS scores in the observation group were (2.3±0.5), (1.1±0.3) and (0.9±0.2), not significantly different compared to [(2.5±0.6), (1.2±0.3) and (1.0±0.3), respectively, P＞0.05] in the control; the Ramsay scores in the observation group were (2.4±0.5), (2.8±0.6) and (3.1±0.7), all significantly greater than [(1.5±0.3), (1.9±0.4) and (2.2±0.5), respectively, P＜0.05] in the control; the incidence of untoward effects in the observation group was 5.4%, much lower than 21.6%(P＜0.05) in the control. Conclusion The application of DEX and BUT combination after LH could obviously improve analgesia and relieve pain, which might improve the recovery of patients with PLC.

Key words: Hepatoma, Laparoscopic hepatectomy, Dexmedetomidine, Butorphanol, Analgesia