Abstract: Objective The aim of this study was to analyze the clinical features of pyogenic liver abscess (PLA)in patients with underlying type 2 diabetes mellitus(T2DM). Methods 54 patients with PLA with underlying T2DM and 72 patients with PLA without T2DM were encountered in our hospital between January 2016 and December 2021, and dealt with antibiotics, puncture aspiration and catheter drainage alone or combination for one month. Results The age of patients with T2DM was (58.6±8.4)yr, significantly greater than [(54.2±9.7)yr, P<0.05], the disease period was (27.5±8.1)d, significantly longer than [(17.1±4.9), P<0.05], and the coincidence of cardiovascular diseases was 24.1%, significantly higher than 9.7%(P<0.05) in patients without T2DM; the incidences of abdominal pain, distension, jaundice and weight loss in patients with T2DM were 63.0%, 64.8%, 25.9% and 92.6%, all significantly higher than 19.4%, 11.1%, 12.5% and 62.5% (P<0.05) in patients without T2DM; at presentation, the white blood cell counts, the percentage of neutrophil cells and serum albumin level in patients with T2DM were (17.8±5.2)×10⁹/L,(74.6±7.5)% and (28.4±4.8)g/L, all significantly lower than[(22.2±4.6)×10⁹/L, (85.2±9.3)% and (35.6±6.3)g/L, respectively, P<0.05], while serum bilirubin level was (30.8±4.8)μmol/L, much higher than [(16.5±3.4)μmol/L, P<0.05] in patients without T2DM; the percentage of antibiotic therapy alone in patients with T2DM was 22.2%, much lower than 38.9%, while that of catheter drainage and antibiotic combination therapy was 48.1%, much higher than 33.3% (P<0.05) in patients without T2DM; at the end of one-month treatment, the recovery rate and becoming chronic abscess in patients with T2DM were 74.1% and 24.1%, significantly different compared to 87.5% and 12.5% in patients without T2DM (P<0.05). Conclusion The patients with PLA with underlying T2DM have a relatively severe clinical symptoms and poor prognosis, which might be carefully paid attention to and deal with appropriately.

Key words: Pyogenic liver abscess, Type 2 diabetes mellitus, Clinical feature, Outcomes