Abstract: Objective This study was to conducted to compare the clinical efficacy of laparoscopic hepatectomy (LH) and traditional open surgery (OS) in the treatment of patients with giant hepatic hemangioma (GHH). Methods 54 patients with GHH were encountered in our hospital between June 2012 and January 2022, and were divided into two groups, receiving LH (n=30) or traditional open surgery (n=24) treatment. The clinical data before and after operation in the two groups were compared. Results The tumor diameter, the percentages of tumors in the left, right and both lobes in LH-surgery-treated patients were (12.2±2.5)cm, 30.0%, 46.7% and 23.3%, all not significantly different compared to [(11.3±1.9)cm, 29.2%, 54.2% and 16.7%, respectively, P>0.05] in open surgery-treated patients; the intra-operational blood loss in LH-treated patients was (188.3±70.5)ml, much less than [(285.6±116.5)ml, P<0.05], while the blocking time of hilus hepatis was (26.2±10.2)min, much longer than [(15.2±9.7)min, P<0.05] in open surgery-treated patients; the drainage volume in LH-treated patients was (180.5±72.6)ml, much less than [(282.3±102.8)ml, P<0.05], the post-operational hospital stay was (8.2±2.8)days, significantly shorter than [(11.6±3.2)days, P<0.05], and serum C-reactive protein and procalcitonin levels were (31.8±14.4)mg/L and (0.1±0.1)ng/ml, significantly lower than [(56.4±20.5)mg/L and (0.2±0.1)ng/ml, respectively, P<0.05] in open surgery-treated patients. Conclusion The application of LH in the treatment of patients with GHH is safe and feasible, which might be lead to mild systemic inflammatory reactions, and relatively faster recovery after operation.

Key words: Giant hepatic hemangioma, Laparoscopic hepatectomy, Blocking hilus hepatis, Procalcitonin, Therapy