Abstract: Objective The aim of this study was to explore the application of contrast-enhanced ultrasound (CEUS) parameters in the quantitative diagnosis of patients with hepatocellular carcinoma (HCC). Methods 50 patients with HCC and 5o patients with liver cirrhosis were admitted to our hospital between January 2018 and May 2021, and the diagnoses in all patients were confirmed by pathological examination after liver biopsies. The CEUS was conducted to obtain the peak intensity (PI), the time to peak (TTP), mean trasit time (mTT), the rise time (RT), and the blood perfusion feature was recorded. Results The local blood volume and local blood flow during arterial phase in patients with HCC were (3399.7±783.7) rBV and (64.1±18.7) rBF, significantly higher than [(1363.8±773.5) rBV and (41.9±10.6) rBF, respectively, P<0.05] in patients with cirrhosis, and the local blood volume during venous and delayed phases were (1325.8±546.3) rBV and (463.2±143.2) rBF, significantly lower than [(1775.4±541.3) rBV and (721.2±242.5) rBF, P<0.05] in patients with cirrhosis; the RT, TTP and mTT in cancerous foci were (15.7±8.3) s, (22.6±5.4) s and (133.5±92.3)s, significantly lower than [(26.3±6.4)s, (32.3±7.6)s and (160.4±112.8)s, respectively, P<0.05], while the PI was (85.2±48.2)dB, significantly higher than [(31.5±3.5)dB, P<0.05] in patients with cirrhosis; at the base of histopathological diagnosis as the gold criteria, the sensitivity, specificity and accuracy by CEUS diagnosis were 92.0%, 92.0% and 80.0%. Conclusion The CEUS quantitative parameters could help the diagnosis of patients with HCC, which is of great clinical application.

Key words: Hepatocellular carcinoma, Contrast-enhanced ultrasound parameter, Diagnosis