Abstract: Objective The aim of this study was to investigate the clinical application of MSCT and MRI dynamic enhanced scans in diagnosing patients with intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) with high blood supply. Methods A total of 70 patients with primary liver cancer were admitted to our hospital between January 2018 and June 2019, and all underwent MSCT and MRI dynamic enhanced scans. The post-operational histopathological examination was performed as a gold diagnostic criterion. Results The post-operational histopathological examination showed 12 patients with ICC, and 58 patients with HCC in our series; the MSCT multi-phase enhancement demonstrated arterial phase enhancement, venous phase enhancement decline and even enhancement decline in delayed phase in 53 patients with HCC, and arterial phase enhancement, continuous portal phase and delayed phase enhancement in 7 lesions in 12 patients with ICC; the MRI multi-phase enhancement found in 58 patients with HCC having 39 lesions of fast-in and fast-out type enhancement, having 17 lesions of fast-in and slow-out, and having 2 lesions of slow-in and slow-out, and in 12 patients with ICC having 9 lesions of slow-in and slow-out type and having 3 lesions without significant enhancement in arterial and portal phases and with gradually enhancement in delayed phase; the MRI scan made a correct diagnosis of HCC in 56 patients (96.6%), not significantly different compared to in 53 cases (91.4%) by MSCT scan (P>0.05), while it found ICC in 9 patients (75.0%) with ICC, significantly higher than in 7 patients (58.3%) by CT scan (P<0.05). Conclusion There are imaging differences in patients with ICC and HCC with rich blood supply, and the MRI scan might improve diagnosing patients with ICC earlier, which warrants further clinical investigation.

Key words: Intrahepatic cholangiocarcinoma, Hepatocellular carcinoma, Multi-slice spiral computed tomography, Magnetic resonance imaging, Diagnosis