Abstract: Objective To investigate the clinical efficacy of entecavir combined with live bifidobacterium and lactobacillus tablets in the treatment of B patients with decompensated liver cirrhosis. Methods 120 patients with hepatitis B induced decompensated liver cirrhosis in the Affiliated Hospital of the Southwest Medical University between Jan. 2015 and Aug. 2017 were randomly divided into control and observation groups. The patients in the control group were administrated entecavir and patients in the observation group were administrated entecavir and live bifidobacterium and lactobacillus tablets. The index of liver function,hepatic fibrosis,HBV DNA and the rate of spontaneous bacterial peritonitis were compared between the two groups. Results At the end of 12 weeks,serum levels of ALT and TBIL in combination treatment group were（70.2±6.2） U/L and（16.3±4.2） μmol/L,both significantly lower than （76.2±9.6） U/L and （26.3±5.2） μmol/L in the control group（P<0.05）;serum level of ALB in the treatment group was （32.5±4.2） g/L,significantly higher than（30.2±5.3）g/L in the control group（P<0.05）;at the end of 24 weeks,serum levels of ALT and TBIL in the treatment group were （12.2±3.2） U/L and（6.2±1.3） μmol/L,both significantly lower than （26.4±3.2）U/L and （11.2±3.2） μmol/L in the control group （P<0.05）;serum level of ALB in the treatment group was （37.8±2.3） g/L,significantly higher than （34.4±4.2） g/L in the control group （P<0.05）;serum LN and C- IV were （65.2±15.1）ng/ml and （85.5±8.5）ng/ml,much lower than【（75.3±10.3）ng/ml and （96.2±10.3）ng/ml in the control,respectively,P<0.05】;serum HBV DNA level was （1.0±0.1）lg copies/ml,no significantly different as compared to （1.7±0.3） lg copies/ml in the control （P>0.05）,and serum HBV DNA negativity rate was 100.0%,also no significantly different as compared to 90.0% in the control（P>0.05）;at the end of 12 w and 24 w,the SBP occurred in 5（8.3%） and in 2（3.3%）,significantly lower than in 10（16.7%） and in 8（13.3% in the control （P<0.05）;at the end of 24 w,3（5%） died in the combination group,much lower than 10（16.7%） in the control（P<0.05）. Conclusion Entecavir combined with live bifidobacterium and lactobacillus tablets has a good clinical efficacy in treatment of hepatitis B patients with decompensated liver cirrhosis,which is worth further investigation.

Key words: Liver cirrhosis, Hepatitis B, Entecavir, Live bifidobacterium and lactobacillus tablets, Therapy