Abstract: Objective To investigate the differences in endothelial function between patients with chronic hepatitis B（CHB）,nonalcoholic fatty liver disease（NAFLD） and CHB with NAFLD. Methods The peripheral arterial tension determination （PAT） of patients with CHB（n=32）,NAFLD（n=35） and CHB combined with NAFLD （n=44） was detected by Endo-PAT 2000 endothelial function testing instrument,and the vascular reactivity congestion index （RHI） was calculated. The biochemical index,such as fasting plasma glucose（FPG）,alanine amino transferase （ALT）,aspartate aminotransferase （AST）,total cholesterol （TC）,total glycerine （TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,lipoprotein a（ApoA）,load of apolipoprotein B （apoB）,lipoprotein a （LP-A） and free fatty acid （FFA） were also analyzed. Results The levels of RHI in patients with NAFLD （1.95±0.44） was higher than that in patients with CHB [（1.68±0.28）,P<0.05];the levels of body mass index（BMI）,TG,TC,LDL-C and apoB in patients with NAFLD [（24.77±3.13）kg/m²,（1.52±0.70）mmol/L,（4.32±0.1.32）mmol/L,（10.72±46.51）mmol/L,（0.90±0.20） g/L]and in patients with CHB and NAFLD[（25.79±2.80）kg/m²,（1.68±0.89）mmol/L,（4.18±1.18）mmol/L,（2.71±0.96）mmol/L,（0.85±0.28）g/L] were higher than those in patients with CHB [（22.63±3.14） kg/m²,（0.89±0.26）mmol/L,（3.51±0.74）mmol/L,（2.23±0.56） mmol/L,（0.68±0.15） g/L,P<0.01]. Conclusion The endothelial function and lipid metabolism may be different between patients with CHB and NAFLD.

Key words: Chronic hepatitis B, Non alcoholic fatty liver disease, Endothelial function, Lipid metabolism