Abstract: Objective To analyze the characteristics of tongue and pulse parameters in patients with chronic hepatitis B （CHB）,and to provide evidence for the clinical syndrome differentiation of Traditional Chinese Medicine（TCM） in patients with CHB. Method Tongue and pulse parameters of 120 patients with CHB and 45 health persons were detected and analyzed by DS01-A type digital tongue and pulse presentation analyzer. Results Compared with those in the healthy controls,the pulse parameters of h3/h1,h4/h1,W/t in patients with CHB increased,while h5/h1 decreased, and the difference was statistically significant （P<0.05）;the h3/h1 and h4/h1 of patients in damp heat group were higher than those of patients with yin deficiency of liver and kidney group（P<0.05）,but h3/h1 in patients of liver stagnation and spleen deficiency group was higher than that of patients with yin deficiency of liver and kidney（P<0.05）;Compared with the healthy control group,tongue parameters including R,G,B,V values in patients with CHB decreased and S value increased,and the difference was statistically significant（P<0.05）;Compared with the blood stasis group,the R values of patients with damp heat with liver stagnation and spleen deficiency or yin deficiency of liver and kidney increased（P<0.05）,but B values decreased（P<0.05）;The S values of patients with damp heat with liver stagnation and spleen deficiency were lower than that of patients with blood stasis（P<0.05）;The B value of patients with yin deficiency of liver and kidney was higher than that of patients with damp heat（P<0.05）. Conclusion Detection of the tongue and pulse parameters can reflect the change of liver functions in patients with CHB,and provide evidence for the clinical syndrome differentiation of TCM.

Key words: Chronic hepatitis B, Tongue and pulse parameters, Digital tongue and pulse presentation analyzer