Abstract: Objective To analyze the Helicobacter pylori（Hp） infection status in Uygur patients with chronic hepatitis B in Xinjiang and helicobacter 16SrRNA gene in liver biopsy tissues. Methods 60 patients with hepatitis B and 80 healthy persons were recruited in this study. ¹⁴C-urea breathing test was used to detected Hp infection,and helicobacter 16SrRNA gene in liver biopsy tissues were detected by using real-time PCR and pathological examination was applied to determine histological activity index. Results The ¹⁴C-UBT positive rate was 85.00% in patients with hepatitis B,significantly higher than 60.24% in the controls （P<0.01）; 14 out of 60 patients with hepatitis B were diagnosed with liver cirrhosis by histopathological examination; the positive rate of helicobacter 16SrRNA in liver tissues from patients with CHB were 86.96%,without significant difference as compared to 92.86% from patients with liver cirrhosis（x²=0.363,P>0.05）;there were no significantly statistical differences as respect to the positive rates of helicobacter 16SrRNA in liver tissues among 21,16 and 9 patients with hepatitis B of mild,moderate and severe degree（x²=1.348,P=0.510）. Conclusion The infection of Hp in patients with CHB is common,but there is no significant evidence showing correlation of the specificity 16SrRNA of Hp to pathological grading and staging in liver tissues.

Key words: Chronic hepatitis B, Helicobacter pylori, 16SrRNA of Hp, Liver biopsy