Toll样受体在肝衰竭发病中的作用研究进展*

doi:10.3969/j.issn.1672-5069.2014.06.029

Abstract

Abstract: Liver failure caused by many etiologies,is a deficiency of liver. Its pathogenesis still remains unclear, and it might involve necrosis,apoptosis and regeneration of the hepatocytes,and fibrosis of the liver. As a kind of pattern recognition receptor,Toll-like receptors（TLRs） link the innate and adaptive immune response,and play an important role in the pathogenesis of liver failure. Animal experiments and clinical studies have demonstrated that TLRs are related to the necrosis of liver cells. Liver injury which is caused by different agents,such as LPS,D-GalN, ConA,CpG ONA,Poly（I:C）and APAP,needs different TLRs signaling. TLR3,TLR4 and TLR9 signaling can promote apoptosis of liver cells. TLR7 signaling has a protective effect against liver fibrosis. Research on TLR polymorphism can reveal the pathogenesis of liver failure from the host aspect, and provide evidences for individualized diagnosis and treatment of patients with liver failure.

Key words: Liver failure, Toll like receptor, Apoptosis

Xue Yuan, Han Yue, Zhang Xinxin. Toll-like receptors in pathogenesis of liver failure[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2014, 17(6): 665-669.

References

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Toll-like receptors in pathogenesis of liver failure

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