Abstract: Objective To investigate the effectiveness and impact on liver function of two different chemotherapy regimens in treatment of patients with pulmonary tuberculosis complicated by chronic hepatitis B. Methods One hundred and sixteen patients with pulmonary tuberculosis and chronic hepatitis B were recruited in our hospital from October 2010 to December 2012. The patients were then randomly divided into two groups. Patients in control group （n=58） were treated with 2HRZE/4HR for half a year,and patients in observation group（n=58） were treated with 3HESG/9HEG for one year. The effectiveness,impact on liver function and adverse reactions were recorded and compared between the two groups. Results Total efficiency,rate of bacteriologic conversion of sputum,rate of focus absorption,rate of cavity shrinking and rate of cavity closure in patients in observation group were 98.3%,87.9%,94.8%,93.1%and 79.3%,respectively,significantly higher than in the controls（87.9%,65.5%,75.9%,72.4%and 54.3%,respectively）;AST,ALT,TBIL,ALB and INR and restoration time of abnormal liver function in observation group were （51.7±6.8） U/L,（52.3±7.2） U/L,（26.4±5.7） μ mol/L,（37.8±7.6） g/L,（1.1±0.4）and （16.7±5.8） d,significantly lower or less than in the controls[（69.3±12.1） U/L,（70.5±11.3） U/L,（36.5±4.3） μmol/L,（48.5±9.2） g/L,（1.5±0.6）and（28.9±10.3） d,respectively];incidence of abnormal liver function and adverse reaction rates in patients in observation group were 29.3% and 3.4%,significantly lower than in the controls（62.1% and 15.5%,respectively）;time for appearance of abnormal liver function in observation group was（35.7±9.6） d,significantly longer than in the controls[（17.4±8.2）d,P<0.05]. Conclusions Chemotherapy with 3HESG/9HEG for one year is safe and effective in treatment of patients with pulmonary tuberculosis complicated by chronic hepatitis B,with low incidence and later occurrence of liver injury.

Key words: Pulmonary tuberculosis, Chronic hepatitis B, Chemotherapy, Effectiveness, Drug induced liver injury