药物性肝损伤诊断进展

doi:10.3969/j.issn.1672-5069.2014.04.032

Abstract

Abstract: Drug-induced liver injury (DILI) refers to varying degrees of liver damage which caused by the drug itself or its metabolites. In recent years, there has been an increasing number of reports about DILI. However, it is often misdiagnosed for the low incidence of DILI symptoms and lack of specificity. There are various diagnostic criteria of DILI in different countries. So it is of great significance to compare the advantages and disadvantages of these criteria and to find the best diagnostic strategy for early treatment and prognosis of DILI.

Key words: Drug-induced liver injury, Diagnostic criteria, Progress

Wang Qingqing, Hu Xiaona, BaoZhijun. Progress in the diagnosis of drug-induced liver injury[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2014, 17(4): 441-444.

References

[1] Leise MD,Poterucha JJ,Talwalkar JA. Drug-induced liver injury. Mayo Clin Proc,2014,89:95-106.
[2] Lazarou J,Pomeranz BH,Corey PN. Incidence of adverse drug reactions in hospitalized patients:a meta-analysis of prospective studies. JAMA,1998,279:1200-1205.
[3] Wai CT. Presentation of drug-induced liver injury in Singapore. Singapore Med J,2006,47:116-120.
[4] Lopez AM,Hendrickson RG. Toxin-induced hepatic injury. Emerg Med Clin North Am,2014,32:103-125.
[5] Hussaini SH,Farrington EA. Idiosyncratic drug-induced liver injury:an overview. Expert Opin Drug Saf,2007,11:673-684.
[6] Giordano CM,Zervos XB. Clinical manifestations and treatment of drug-induced hepatotoxicity. Clin Liver Dis,2013,17:565-573.
[7] Watanabe M,Shibuya A. Validity study of a new diagnostic scale for drug-induced liver injury in Japan-comparison with two previous scales. Hepatol Res,2004,30:148-154.
[8] García-Cortés M,Lucena MI,Pachkoria K,et al. Evaluation of naranjo adverse drug reactions probability scale in causality assessment of drug-induced liver injury. Aliment Pharmacol Ther,2008,27:780-789.
[9] Danan G. Causality assessment of drug-induced liver injury. J Hepatol,1988,7:132-136.
[10] Standardization of definitions and criteria of causality assessment of adverse drug reactions. Drug-induced liver disorders:report of an international consensus meeting.Int J Clin Pharmacol Ther Toxicol,1990,28:317-22.
[11] Danan G,Benichou C.Causality assessment of adverse reactions to drugs-I. A novel method based on the conclusions of international consensus meetings:application to drug-induced liver injuries. J Clin Epidemiol. 1993,46:1323-1330.
[12] Rochon J,Protiva P,Seeff LB,et al. Reliability of the roussel uclaf causality assessment method for assessing causality in drug-induced liver injury. Hepatology,2008,48:1175- 1183.
[13] García-Cortés M,Stephens C,Lucena MI,et al. Causality assessment methods in drug induced liver injury:Strengths and weaknesses. J Hepatol,2011,55:683-691.
[14] Maria VA,Victorino RM. Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology,1997,26:664-669.
[15] Usui K,Oda Y,Kubota R,et al. Clinical application of the leukocyte migration test and new diagnostic criteria for identifying causative agents in patients with drug-induced liver injury. Hepatogastroenterology,2007,54:1752-1757.
[16] Saito M,Yagi M,Uno K,et al. Comparative study of the usefulness of the drug-induced lymphocyte stimulation test and the leukocyte migration test in drug allergies. Biol Pharm Bull,2008, 31:299-304.
[17] 万瑜,杨冬华.药物性肝损害诊治研究近况.新医学,2005,6：476-477.
[18] 刘思纯,马博. 两种急性药物性肝病诊断标准的评价及临床应用比较-附202例报告. 新医学,2009,40:21-23.
[19] Ju HY,Jang JY,Jeonq SW,et al. The clinical features of drug-induced liver injury observed through liver biopsy:focus on relevancy to autoimmune hepatitis. Clin Mol Hepatol,2012,18:213-218.
[20] Grant LM,Rockey DC. Drug-induced liver injury. Curr Opin Gastroenterol,2012,28:198-202.
[21] Teschke R,Frenzel C.Drug induced liver injury:do we still need a routine liver biopsy for diagnosis today Ann Hepatol, 2013-2014,13:121-126.
[22] Bjornsson E,Kalaitzakis E,Olsson R. The impact of eosinophilia and hepatic necrosis on prognosis in patients with drug-induced liver injury. Aliment Pharmacol Ther,2007,25:1411-1421.
[23] 唐岸柳,沈守荣,贺达仁. 药物性肝损害的诊断思维. 医学与哲学（临床决策论坛版）,2009,30：63-65.
[24] 宋文艳,赵大伟,陈煜,等. 药物性肝损害的多层螺旋CT影像表现. 中华放射学杂志,2010,44：1171-1175.
[25] 赵新湘,马悦,王家平,等. 急性药物性肝损伤MRI诊断价值探讨. 中国临床医学影像杂志,2011,22：665-667.
[26] Lucena MI,Camargo R,Andrade RJ,et al. Comparison of two clinical Scales for causality assessment in hepatotoxicity. Hepatology,2001,33:123-130.
[27] 于涛,文卓夫. 两种药物性肝病诊断标准的对比研究.中国现代医学杂志,2007,17：1257-1259.
[28] 陈高艳,陈成伟,傅青春,等. 药物淋巴细胞刺激试验及其在药物性肝病诊断中的应用. 中华肝脏病杂志,2012,20：190-192.
[29] Iwasa M,Zeniya M,Kumagi T,et al. Modified diagnostic criteria of drug-induced liver injury proposed by the international consensus meeting. Hepatogastroenterology,2005,52:869-874.
[30] Miljkovic MM,Dobric S,Dragojevic-Simic V. Accuracy and reproducibility of two scales in causality assessment of unexpected hepatotoxicity. J Clin Pharm Ther,2012,37:196-203.
[31] Michaut A,Moreau C,Robin MA,et al. Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease. Liver Int,2014,28:10.1111.
[32] Kancherla D,Gajendran M,Vallabhaneni P,et al. Metronidazole induced liver injury:a rare immune mediated drug reaction. Case Rep Gastrointest Med,2013:568193.
[33] 苗琪,马雄. 自身免疫性肝炎与药物性肝损伤：鉴别诊断和处理. 中华肝脏病杂志,2012,5：327-329.
[34] Zinmlerman HJ. Drug-induced liver disease. Clin Liver Dis, 2000,4:73-96.
[35] Teschke R,Frenzel C,Wolff A,et al. Drug induced liver injury:accuracy of diagnosis in published reports. Ann Hepatol, 2014,13:248-55.
[36] Chen M,Bisgin H, Tong L,et al. Toward predictive models for drug-induced liver injury in humans:are we there yet Biomark Med,2014,8:201-213.

Progress in the diagnosis of drug-induced liver injury

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Du Keye, Yang Dongliang, Liu Jia. Regulatory T cells in hepatitis B [J]. Journal of Practical Hepatology, 2019, 22(5): 613-616.
[2]	Liu Liwei, Zhao Xinyan. Clinicopathological features of drug-induced liver injury [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(2): 160-163.
[3]	Huang Chunyang, Shan Jing, Liao Huiyu, Huang Yunli, Han Ying, Zhang Xiaodan, Du Xiaofei, Ren Meixin, Bian Xinqu, Liu Yanmin. Clinical and laboratory characteristics of patients with drug-induced liver injury receiving glucocorticoid therapy [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(2): 208-211.
[4]	Wu Xiuxin, Zhang Huiyong, Zhang Kai. Changes of plasma microRNA-4284 in patients with anti-tuberculosis drug-induced hepatotoxicity [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(2): 212-215.
[5]	Sun Wenjing, Chen Dongfeng.. Literature analysis about RUCAM scale and Maria scale in diagnosis of Chinese patients with drug-induced liver injury [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2018, 21(6): 881-884.
[6]	Tong Xin, Fan Hua. Efficacy of bicyclic alcohol on liver function in gastric cancer patients with chemotherapy-induced liver injury [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2018, 21(4): 625-626.
[7]	Liu Cong, Wang Tingting, Zuo Lili, et al. Analysis of patients with drug-induced liver injury in recent 3 years [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2018, 21(4): 639-640.
[8]	Liu Liangyi, Su Dongyuan. Comparison of clinical and liver pathological features of patients with drug-induced liver injury and autoimmune hepatitis [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2018, 21(3): 463-464.
[9]	Wei Lujia, Li Qingxiang, Ji Qingwei.. Clinical features of amiodarone-induced acute liver injury [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2017, 20(4): 424-426.
[10]	Yu Hongxing Chen Ying Liu Zipeng, et al.. Comparison of ultrasound-guided percutaneous laser ablation and radiofrequency ablation for the treatment of patients with small hepatocellular carcinoma [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2017, 20(3): 320-323.
[11]	Zhang Dai，Wang Bingyuan.. Novel medicines, new members of drug-induced liver injury [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2017, 20(2): 129-131.
[12]	Wang Yuxia，Du Jian.. Diagnostic and therapeutic progress in anti-thyroid drug -induced liver injury [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2017, 20(2): 135-138.
[13]	Zheng Kai，Li Hai.. Hepatotoxicity of lipid-lowering agents [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2017, 20(2): 139-141.
[14]	Zhou Xueshi，Yin Cuilan，Lu Zhonghua，et al.. Drug-induced liver injury：a report of two cases [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2017, 20(2): 250-251.
[15]	Lei Wei，Wang Dandan，Ge Guangb，et al.. Serum biomarkers of liver injury [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2017, 20(2): 252-254.