Abstract: Objective To investigate the complications and death causes，and their relationship，in patients with liver failure. Methods The age，gender，etiology，complication，and prognosis of the 1892 patients with liver failure were retro-prospectively analyzed. Results There were 1206（63.74%） cases of male and 686 cases（36.26%） of female included in this study，with an average age of（48.9±11.3） years；The major causes of liver failure included hepatitis B virus infection（1319，69.7%），hepatitis E virus infection（102，5.4%），drug-induced liver injury（102，5.4%），alcohol （89，4.7%）and unknown etiology（107，5.7%）；A total of 1543 patients with liver failure suffered from complications including infection，hemorrhage，hepatic encephalopathy，hepatorenal syndrome，and encephaledema，and their incidence were 69.82%，30.97%，23.04%，16.97%，and 2.59%，respectively；The incidences of hepatic encephalopathy（77.14%），hepatorenal syndrome（45.71%），and encephaledema（20.0%） were significantly higher in patients with acute liver failure than all other kinds of liver failure（P<0.05）；The mortality of patients with encephaledema was 100%，while the mortality of patients with hepatorenal syndrome was 90.65%；The mortality of 1092 patients with one complication was 62.09%，and 288 patients with two complications was 78.47%；Furthermore，the mortality of 163 patients with three or more complications was up to 98.16%. Conclusion Patients with liver failure was prone to suffering from complications，and the most common complication was infection，while the worst complications were encephaledema and hepatorenal syndrome；The mortality of patients with liver failure increases with the numbers of complications.

Key words: Liver failure, Complications, Death cause