Abstract: Objective To study the relationship between variation of calponin（CaP） expression and liver microcirculation disturbance of CHB. Method The liver biopsies samples from 200 patients with chronic hepatitis B（CHB） and 10 normal liver biopsies were stained for CaP expression by immunohistochemonical method. Results In control，CaP expression was showed in blood vessel and bile duct；In sinusoidal and microangiopathy mild （G1，G2） groups，CaP expression were showed dispersion or interrupt on hepatocyte，endotheliocyte and fat storing cell of domain of inflammation with vasculitis in hepatic tissue，and the positive was majority and a few showed negative and strong positive occupied 6%；But，in severe groups，not only CaP expression was showed diffuse by hepatocytes，but also there were all CaP expression in the liver sinusoidal walls and domain of capillarization and muscle fiber bundle. CaP expression ratio of strong positive was upgraded by degrees with sinusoidal expansion and vascular rebuilding or fibrosis. Between of the interclass was significantlly difference（P<0.01）. Conclusion The variation of CaP expression was related to abnormal microcirculation in livers of CHB.

Key words: Chronic hepatitis B, Calponin, Liver microcirculation