关键词: 新型冠状病毒肺炎, 肝肾功能, 心肌酶学, 预后

Abstract: Objective The aim of this study was to analyze the changes of serum liver and kidney function tests and cardiac muscle enzymes in patients with coronavirus-19 (covid-19) pneumonia.Methods The clinical materials in 112 patients with covid-19 pneumonia were retrospectively analyzed and it included typical type in 68, severe type in 22 and critical type in 22. Serum liver and kidney function tests and myocardial enzyme cardiac troponin Test (cTnT), myohemoglobin (Myo)and creatine kinase Isoenzyme-MB (CK-MB) levels were determined routinely.Results There was no significant difference as respect to serum renal function tests in the three groups (P>0.05); the abnormal incidences of serum ALT and AST in critical patients were 31.8% and 45.5%, much higher than 4.6% and 13.6% (P<0.05)in severe ones or 0.0% and 2.9% (P<0.05) in patients with typical ones; the abnormal elevated incidences of serum cTnT, Myo and CK-MB in critical patients were 72.7%, 45.5% and 27.3%, significantly higher than 22.7%, 16.6% and 9.1%, respectively (P<0.05) in severe patients or 4.4%, 1.5% and 1.5%, respectively (P<0.05) in typical patients; out of 24 patients with abnormal serum myocardial enzyme, the fatality rate was 25%, much higher than 1.1%(P<0.05) in 88 patients with normal serum myocardial enzyme.Conclusion The results from a single-centered retrospective study suggest that the patients with covid-19 pneumonia could have serum myocardial enzyme elevation, which might hint the critical clinical type and poor prognosis.

Key words: Coronavirus-19 pneumonia, Liver and kidney function tests, Myocardial enzymes, Prognosis