新生儿发生高胆红素血症危险因素分析

doi:10.3969/j.issn.1672-5069.2019.04.021

摘要/Abstract

摘要： 目的探讨影响新生儿发生高胆红素血症的危险因素。方法 2015年5月~2018年2月我院诊治的高胆红素血症新生儿86例和同期健康新生儿86例,采用Logistic多因素分析影响新生儿发生高胆红素血症的危险因素。结果高胆红素血症新生儿出生体质量低、胎龄短和剖腹产分娩比例高,与健康新生儿比,差异显著（P<0.05）;高胆红素血症新生儿血清肌红蛋白（MYO）和前白蛋白（PA）水平为（37.5±13.6） U/L和（79.9±23.5）U/L,显著低于健康新生儿【分别为（63.2±18.4） U/L和（108.6±27.3） U/L,P<0.05】,谷氨酰转肽酶（GGT）和谷草转氨酶（AST）水平分别为（141.7±45.9） U/L和（39.8±13.1） U/L,显著高于健康新生儿【分别为（113.6±39.3） U/L和（33.4±12.6） U/L,P<0.05】;多因素Logistic 回归分析显示,新生儿出生体质量（OR=6.2,P=0.003）、胎龄（OR=2.8,P=0.004）、MYO（OR=3.4,P<0.001）、PA（OR=2.9,P=0.001）、GGT（OR=3.2,P=0.011）、AST（OR=3.7,P=0.024）水平和凝血功能指标为影响新生儿发生高胆红素血症的相关危险因素（P<0.05）。结论高胆红素血症新生儿存在肝功能受损,对新生儿高胆红素血症相关危险因素进行监测并及时采取措施干预将有助于降低其危害。

关键词: 高胆红素血症, 新生儿, 危险因素, Logistic回归分析

Abstract: Objective To explore the risk factors for occurrence of hyperbilirubinemia in neonates.Methods 86 neonates with hyperbilirubinemia and another 86 healthy neonates were recruited in the Department of Neonatology in our hospital between May 2015 and February 2018,and the Logistic analysis were applied for the analysis of risk factors.Results The proportion of caesarean delivery,short gestational age and decreased body mass at birth in neonates with hyperbilirubinemia were significantly higher than in healthy neonates（P<0.05）;serum level of myoglobin and prealbumin in neonates with hyperbilirubinemia were（37.5±13.6） U/L and（79.9±23.5） U/L,much lower than [（63.2±18.4） U/L and （108.6±27.3）U/L,P<0.05],serum GGT and AST levels were （141.7±45.9） U/L and （39.8±13.1）U/L,significantly higher than[113.6±39.3） U/L and（33.4±12.6） U/L,respectively,P<0.05] in the healthy neonates;multivariate Logistic regression analysis showed that body mass at birth（OR=6.2,P=0.003）,gestational age（OR=2.8,P=0.004）,myoglobin （OR=3.4,P<0.001）,prealbumin （OR=2.9,P=0.001）,GGT（OR=3.2,P=0.011）,AST（OR=3.7,P=0.024） and PT were the risk factors for the occurrence of hyperbilirubinemia in neonates. Conclusion The liver function index in neonates with hyperbilirubinemia are damaged,and monitoring the risk factors related to hyperbilirubinemia and taking timely measures to intervene are helpful to reduce the incidence of untoward outcomes.

Key words: Hyperbilirubinemia, Neonatal, Risk factors, Logistic regression analysis

张微, 史军梅, 王倩. 新生儿发生高胆红素血症危险因素分析[J]. 实用肝脏病杂志, 2019, 22(4): 534-536.

Zhang Wei, Shi Junmei, Wang Qian. Fisk factors for occurrence of hyperbilirubinemia in neonates[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(4): 534-536.

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