[1] European Association for the Study of the Liver. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol,2017,67(2):370-398. [2] 中华医学会肝病学分会和感染病学分会.慢性乙型肝炎防治指南(2015年版).实用肝脏病杂志,2016,19(3):Ⅴ-ⅩⅩⅢ. [3] Sarin SK,Kumar M,Lau GK,et al.Asian-Pacific clinical practice guidelines on the management of hepatitis B:a 2015 update. Hepatol Int,2016,10(1):1-98. [4] Terrault NA,Bzowej NH,Chang KM,et al.AASLD guidelines for treatment of chronic hepatitis B. Hepatology,2016,63(1):261-283. [5] Liang Y,Jiang J,Su M,et al.Predictors of relapse in chronic hepatitis B after discontinuation of anti-viral therapy. Aliment Pharmacol Ther,2011,34(3):344-352. [6] Chen CH,Lu SN,Hung CH, et al.The role of hepatitis B surface antigen quantification in predicting HBsAg loss and HBV relapse after discontinuation of lamivudine treatment. J Hepatol,2014,61(3):515-522. [7] Liu J,Li T,Zhang L,et al. The role of hepatitis B surface antigen in nucleos(t)ide analogues cessation among Asian chronic hepatitis B patients:a systematic review. Hepatology,2018[ahead of print]. [8] Rang A,Bruns M,Heise T,et al.Antiviral activity of interferon-alpha against hepatitis B virus can be studied in non-hepatic cells and Is independent of MxA. J Biol Chem,2002,277(10):7645-7647. [9] Ning Q,Han M,Sun Y,et al.Switching from entecavir to peg IFN alfa-2a in patients with HBeAg-positive chronic hepatitis B:a rando mised open-label trial (OSST trial). J Hepatol,2014,61(4):777-784. [10] Lau GK,Piratvisuth T,Luo KX,et al.Peginterferon alfa-2a, lamivudine,and the combination for HBeAg-positive chronic hepatitis B. N Engl J Med,2005,352(26):2682-2695. [11] Kim GA,Lim YS,An J,et al.HBsAg seroclearance after nucleoside analogue therapy in patients with chronic hepatitis B:clinical outcomes and durability. Gut,2014,63(8):1325-1332. [12] Hu P,Shang J,Zhang W,et al.HBsAg loss with peg-interferon alfa-2a in hepatitis B patients with partial response to nucleos(t)ide analog:New Switch Study. J Clin Transl Hapatol,2018,6(1):25-34. [13] Lampertico P,Vigano M,Di Costanzo GG,et al.Randomised study comparing 48 and 96 weeks peginterferon α-2a therapy in genotype D HBeAg-negative chronic hepatitis B. Gut,2013,62(2):290-298. [14] Xie Q,Cai W,Ouyang LJ,et al. Effectiveness of response-guided peginterferon alfa-2a therapy in nucleos(t)ide analogues treated patients with Hbeag-positive chronic hepatitis B:interim analysis of a prospective,multicenter,randomized study. Hepatology,2018[ahead of print]. [15] Chen JD,Yang HI,IIoeje UH,et al.Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death. Gastroenterology,2010,138(5):1747-1754. [16] McMahon BJ. The natural history of chronic hepatitis B virus infection. Hepatology,2009,49(5S):S45-55. [17] Cao Z,Liu Y,Ma L,et al.A potent hepatitis B surface antigen response in subjects with inactive hepatitis B surface antigen carrier treated with pegylated-interferon alpha. Hepatology,2017,66(4):1058-1066. [18] Li MH,Xie Y,Zhang L,et al.Hepatitis B surface antigen clearance in inactive hepatitis B surface antigen carriers treated with peginterferon alfa-2a. World J Hepatol,2016,8(15):637-643. [19] 闫一杰,王晓晓,曹振环,等. 48周HBsAg低水平的HBeAg阴性慢性乙型肝炎患者是获得HBsAg清除的优势人群. 中华肝脏病杂志,2018,26(11):813-818. |