实用肝脏病杂志 ›› 2019, Vol. 22 ›› Issue (2): 164-171.doi: 10.3969/j.issn.1672-5069.2019.02.004
中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学组
出版日期:
2019-03-10
发布日期:
2019-03-19
作者简介:
李兰娟,浙江大学医学院附属第一医院传染病诊治国家重点实验室,杭州310003,E-mail:ljli@zju.edu.cn;韩涛,天津市第三中心医院肝病内科,300170,E-mail:hantaomd@126.com
Guideline for diagnosis, treatment of liver failure
Online:
2019-03-10
Published:
2019-03-19
Contact:
Corresponding author:Li Lanjuan,Email:ljli@zju.edu.cn,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;
中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊治指南(2018年版)[J]. 实用肝脏病杂志, 2019, 22(2): 164-171.
Guideline for diagnosis, treatment of liver failure. [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(2): 164-171.
[1] Polson J,Lee WM.AASLD position paper:the management of acute liver failure[J]. Hepatology,2005,41(5):1179-1197. DOI: 10.1002/hep.20703. [2] 中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊疗指南[J]. 中华肝脏病杂志,2006,14(9):643-646. Liver Failure and Artificial Liver Group,Chinese Society of Infectious Diseases,Chinese Medical Association;Severe Liver Diseases and Artificial Liver Group,Chinese Society of Hepatology,Chinese Medical Association. Diagnostic and treatment guidelines for liver failure[J].Chin J Hepatol,2006,14(9):643-646. (in Chinese) [3] 中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学组.肝衰竭诊治指南(2012年版)[J].中华临床感染病杂志,2012,5(6):321-327. DOI:10.3969/j.issn.1672-5069.2013.03.007. Liver Failure and Artificial Liver Group,Chinese Society of Infectious Diseases,CMA;Severe Liver Disease and Artificial Liver Group,Chinese Society of Hepatology,CMA. Guideline for diagnosis and treatment of liver failure[J]. Chin J Clin Infect Dis,2012,5(6):321-327. DOI10.3969/j.issn.1672-5069.2013.03.007.(in Chinese) [4] Sarin SK,Kedarisetty CK,Abbas Z,et al.Acute-on-chronic liver failure:consensus recommendations of the Asian Pacific Association for the Study of the Liver(APASL) 2014[J]. Hepatol Int,2014,8(4):453-471. DOI: 10.1007/s12072-014-9580-2. [5] European Association for the Study of the Liver. EASL clinical practical guidelines on the management of acute (fulminant) liver failure[J]. J Hepatol,2017,66(5):1047-1081. DOI: 10.1016/j.jhep.2016.12.003. [6] Flamm SL,Yang YX,Singh S,et al.American gastroenterological association institute guidelines for the diagnosis and management of acute liver failure[J]. Gastroenterology,2017,152(3):644-647. DOI:10.1053/j.gastro.2016.12.026. [7] Wu T,Li J,Shao L,et al.Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure[J]. Gut,2018,67(12):2181-2191. DOI:10.1136/ gutjnl-2017-314641. [8] Jalan R,Yurdaydin C,Bajaj JS,et al.Toward an improved definition of acute-on-chronic liver failure[J]. Gastroenterology,2014,147(1):4-10. DOI:10.1053/j.gastro.2014.05.005. [9] Zhang Q,Li Y,Han T,et al.Comparison of current diagnostic criteria for acute-on-chronic liver failure[J/OL]. PLoS One,2015,10(3):e0122158. DOI:10.1371/journal.pone.0122158. [10] European Association for the Study of the Liver. EASL Clinical Practice Guidelines on nutrition in chronic liver disease[J]. J Hepatol,2018,pii:S0168-8278(18):32177-32179. DOI:10.1016/ j.jhep.2018.06.024. [11] Chen Y,Yang F,Lu H,et al.Characterization of fecal microbial communities in patients with liver cirrhosis[J]. Hepatology,2011,54(2):562-572. DOI:10.1002/hep.24423. [12] Tilg H,Cani PD,Mayer EA.Gut microbiome and liver diseases[J]. Gut,2016,65(12):2035-2044. DOI:10.1136/gutjnl-2016- 312729. [13] Petrof EO,Khoruts A. From stool transplants to next-generation microbiota therapeutics[J]. Gastroenterology,2014,146(6):1573- 1582. DOI: 10.1053/j.gastro.2014.01.004. [14] Rockey DC,Seeff LB,Rochon J,et al.Causality assessment in drug-induced liver injury using a structured expert opinion process:comparison to the Roussel-Uclaf causality assessment method[J]. Hepatology,2010,51(6):2117-2126. DOI: 10.1002/ hep.23577. [15] Jindal A,Kumar M,Sarin SK. Management of acute hepatitis B and reactivation of hepatitis B[J]. Liver Int,2013,33 Suppl 1:164-175. DOI:10.1111/liv.12081. [16] Sun LJ,Yu JW,Zhao YH,et al.Influential factors of prognosis in lamivudine treatment for patients with acute-on-chronic hepatitis B liver failure[J]. J Gastroenterol Hepatol,2010,25(3):583-590. DOI:10.1111/j.1440-1746.2009.06089.x. [17] European Association for the Study of the Liver. EASL recommendations on treatment of hepatitis C 2018[J]. J Hepatol,2018,69(2):461-511. DOI:10.1016/j.jhep.2018.03.026. [18] Smilkstein MJ,Knapp GL,Kulig KW,et al.Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)[J]. N Engl J Med,1988,319(24):1557-1562. DOI: 10.1056/NEJM198812153192401. [19] Keays R,Harrison PM,Wendon JA,et al.Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure:a prospective controlled trial[J]. BMJ,1991,303(6809):1026-1029. DOI:10.1136/bmj.303.6809.1026. [20] Lee WM,Hynan LS,Rossaro L,et al.Intravenous N-acetylcysteine improves transplant-free survival in early stage non- acetaminophen acute liver failure[J]. Gastroenterology,2009,137(3):856-864. DOI:10.1053/j.gastro.2009.06.006. [21] Hruby K,Csomos G,Fuhrmann M,et al.Chemotherapy of amanita phalloides poisoning with intravenous silibinin[J]. Hum Toxicol,1983,2(2):183-195. [22] Broussard CN,Aggarwal A,Lacey SR,et al.Mushroom poisoning-from diarrhea to liver transplantation[J]. Am J Gastroenterol,2001,96(11):3195-3198. DOI:10.1111/j.1572-0241.2001.05283.x. [23] Enjalbert F,Rapior S,Nouguier-Soulé J,et al.Treatment of amatoxin poisoning:20-year retrospective analysis[J]. J Toxicol Clin Toxicol,2002,40(6):715-757. DOI:10.1081/CLT-120014646. [24] Canalese J,Gimson AE,Davis C,et al.Controlled trial of dexamethasone and mannitol for the cerebral oedema of fulminant hepatic failure[J]. Gut,1982,23(7):625-629. DOI:10.1136/gut.23.7.625. [25] Klinck J,McNeill L,Di Angelantonio E,et al. Predictors and outcome impact of perioperative serum sodium changes in a high-risk population[J]. Br J Anaesth,2015,114(4):615-622. DOI:10.1093/bja/aeu409. [26] Jalan R,Olde Damink SW,Deutz NE,et al.Restoration of cerebral blood flow autoregulation and reactivity to carbon dioxide in acute liver failure by moderate hypothermia[J]. Hepatology,2001,34(1):50-54. DOI:10.1053/jhep.2001.25386. [27] Jalan R,O Damink SW,Deutz NE,et al. Moderate hypothermia for uncontrolled intracranial hypertension in acute liver failure[J]. Lancet,1999,354(9185):1164-1168. DOI:10.1016/S0140 -6736(98)12440-6. [28] Tofteng F,Larsen FS.The effect of indomethacin on intracranial pressure,cerebral perfusion and extracellular lactate and glutamate concentrations in patients with fulminant hepatic failure[J]. J Cereb Blood Flow Metab,2004, 24(7):798-804. DOI10.1097/01.WCB.0000125648.03213.1D. [29] 中华医学会肝病学分会.肝硬化肝性脑病诊疗指南[J]. 中华内科杂志,2018,57(10):705-718. DOI:10.3760/cma.j.issn.0578-1426. 2018.10.004.Chinese Society of Hepatology,Chinese Medical Association. Guidelines on the management of hepatic encephalopathy in cirrhosis[J]. Chin J Intern Med,2018,57(10):705-718. DOI:10.3760/cma.j.issn.0578-1426.2018.10.004.(in Chinese) [30] Vilstrup H,Amodio P,Bajaj J,et al.Hepatic encephalopathy in chronic liver disease:2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver[J]. Hepatology,2014,60(2):715-735. DOI:10.1002/hep.27210. [31] Gluud LL,Vilstrup H,Morgan MY.Nonabsorbable disaccharides for hepatic encephalopathy:A systematic review and meta-analysis[J]. Hepatology,2016,64(3):908-922. DOI: 10.1002/hep.28598. [32] Gluud LL,Vilstrup H,Morgan MY. Non-absorbable disaccharides versus placebo/no intervention and lactulose versus lactitol for the prevention and treatment of hepatic encephalopathy in people with cirrhosis[J]. Cochrane Database Syst Rev,2016(5):p. CD003044. DOI:10.1002/14651858.CD003044.pub4. [33] Bai M,Yang Z,Qi X,et al.L-ornithine-L-aspartate for hepatic encephalopathy in patients with cirrhosis:a meta-analysis of randomized controlled trials[J]. J Gastroenterol Hepatol,2013,28(5):783-792. DOI:10.1111/jgh.12142. [34] Gluud LL,Dam G,Les I,et al. Branched-chain amino acids for people with hepatic encephalopathy[J]. Cochrane Database Syst Rev,2017,5:CD001939. DOI:10.1002/14651858.CD001939.pub4. [35] Laccetti M,Manes G,Uomo G,et al.Flumazenil in the treatment of acute hepatic encephalopathy in cirrhotic patients:a double blind randomized placebo controlled study[J]. Dig Liver Dis,2000,32(4):335-338. [36] Hanish SI,Stein DM,Scalea JR,et al.Molecular adsorbent recirculating system effectively replaces hepatic function in severe acute liver failure[J]. Ann Surg,2017,266(4):677-684. DOI: 10.1097/SLA.0000000000002361. [37] Saliba F,Camus C,Durand F,et al.Albumin dialysis with a noncell artificial liver support device in patients with acute liver failure: a randomized,controlled trial[J]. Ann Intern Med,2013,159(8):522-531. DOI: 10.7326/0003-4819-159-8-2013 10150-00005. [38] Rolando N,Philpott-Howard J,Williams R.Bacterial and fungal infection in acute liver failure[J]. Semin Liver Dis,1996,16(4):389-402. DOI:10.1055/s-2007-1007252. [39] Silvestre JP,Coelho LM,Póvoa PM.Impact of fulminant hepatic failure in C-reactive protein[J]. J Crit Care,2010,25(4):657. e7-12. DOI:10.1016/j.jcrc.2010.02.004. [40] Rule JA,Hynan LS,Attar N,et al.Procalcitonin identifies cell injury,not bacterial infection,in acute liver failure[J/OL]. PLoS One,2015,10(9):e0138566. DOI:10.1371/journal.pone.0138566. [41] Karvellas CJ,Cavazos J,Battenhouse H,et al. Effects of antimicrobial prophylaxis and blood stream infections in patients with acute liver failure:a retrospective cohort study[J]. Clin Gastroenterol Hepatol,2014,12(11):1942-1949. e1. DOI:10.1016/j.cgh.2014.03.011. [42] Bernal W,Auzinger G,Dhawan A,et al.Acute liver failure[J]. Lancet,2010,376(9736):190-201. DOI:10.1016/S0140-6736(10)60274-7. [43] Farmakiotis D,Kontoyiannis DP.Emerging issues with diagnosis and management of fungal infections in solid organ transplant recipients[J]. Am J Transplant,2015,15(5):1141-1147. DOI: 10.1111/ajt.13186. [44] Uojima H,Kinbara T,Hidaka H,et al.Close correlation between urinary sodium excretion and response to tolvaptan in liver cirrhosis patients with ascites[J]. Hepatol Res,2017,47(3):E14-E21. DOI:10.1111/hepr.12716. [45] Yan L,Xie F,Lu J,et al.The treatment of vasopressin V2-receptor antagonists in cirrhosis patients with ascites:a meta-analysis of randomized controlled trials[J]. BMC Gastroenterol,2015,15:65. DOI:10.1186/s12876-015-0297-z. [46] European Association for the Study of the Liver. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis[J]. J Hepatol,2018,69(2):406-460. DOI: 10.1016/j.jhep.2018.03.024. [47] Mindikoglu AL,Pappas SC. New developments in hepatorenal syndrome[J]. Clin Gastroenterol Hepatol,2018,16(2):162-177. e1. DOI:10.1016/j.cgh.2017.05.041. [48] Selby NM,Kubba AK,Hawkey CJ.Acid suppression in peptic ulcer haemorrhage:a 'meta-analysis'[J]. Aliment Pharmacol Ther,2000,14(9):1119-1126. [49] Leontiadis GI,Sharma VK,Howden CW.Proton pump inhibitor therapy for peptic ulcer bleeding:Cochrane collaboration meta-analysis of randomized controlled trials[J]. Mayo Clin Proc,2007,82(3):286-296. DOI:10.4065/82.3.286. [50] Ioannou G,Doust J,Rockey DC. Terlipressin for acute esophageal variceal hemorrhage[J]. Cochrane Database Syst Rev,2003,(1):CD002147. DOI:10.1002/14651858.CD002147. [51] Imperiale TF,Teran JC,McCullough AJ. A meta-analysis of somatostatin versus vasopressin in the management of acute esophageal variceal hemorrhage[J]. Gastroenterology,1995,109(4):1289-1294. [52] Laine L,Cook D.Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding. A meta-analysis[J]. Ann Intern Med,1995,123(4):280-287. [53] Lin LL,Du SM,Fu Y,et al.Combination therapy versus pharmacotherapy,endoscopic variceal ligation,or the transjugular intrahepatic portosystemic shunt alone in the secondary prevention of esophageal variceal bleeding:a meta-analysis of randomized controlled trials[J]. Oncotarget,2017,8(34):57399-57408. DOI: 10.18632/oncotarget.18143. [54] Pereira SP,Rowbotham D,Fitt S,et al.Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K1) in severe acute liver disease[J]. J Hepatol,2005,42(3):365-370. DOI:10.1016/j.jhep.2004.11.030. [55] 中华医学会感染病学分会肝衰竭与人工肝学组. 非生物型人工肝治疗肝衰竭指南(2016年版)[J]. 中华临床感染病杂志,2016,9(2):97-103. DOI:10.3760/cma.j.issn.1674-2397.2016.02.001. Liver Failure and Artificial Liver Group,Branch of Infectious Diseases,Chinese Medical Association. Guideline for non-bioartificial liver support systems in treatment of liver failure:2016 update[J]. Chin J Clin Infect Dis,2016,9(2):97-103. DOI10.3760/cma.j.issn.1674-2397.2016.02.001.(in Chinese) [56] Steadman RH,Van Rensburg A,Kramer DJ.Transplantation for acute liver failure:perioperative management[J]. Curr Opin Organ Transplant,2010,15(3):368-373. DOI:10.1097/MOT.0b013e32 833982dd. [57] Ling Q,Xu X,Wei Q,et al.Downgrading MELD improves the outcomes after liver transplantation in patients with acute-on-chronic hepatitis B liver failure[J/OL]. PLoS One,2012,7(1):e30322. DOI: 10.1371/journal.pone.0030322. [58] Mochida S. Indication criteria for liver transplantation for acute liver failure in Japan[J]. Hepatol Res,2008,38 Suppl 1:S52-55. DOI:10.1111/j.1872-034X.2008.00427.x. [59] 饶慧瑛,郭芳,魏来. 2005年美国肝病学会急性肝衰竭诊治和肝移植患者评价指南简介[J].中华肝脏病杂志,2006,14(2):154-156. DOI:10.3760/j.issn:1007-3418.2006.02.025. Rao HY, Guo F,Wei L. Introduction and comments on AASLD practice guidelines:diagnosis and treatment of acute liver failure and assessment of liver transplant patients[J].Chin J Hepatol,2006,14(2):154-156. DOI10.3760/j.issn:1007-3418.2006.02.025. (in Chinese) [60] Arroyo V,Moreau R,Kamath PS,et al.Acute-on-chronic liver failure in cirrhosis[J]. Nat Rev Dis Primers,2016,2:16041. DOI: 0.1038/nrdp.2016.41. [61] Linecker M,Krones T,Berg T,et al. Potentially inappropriate liver transplantation in the era of the “sickest first” policy-A search for the upper limits[J]. J Hepatol,2017,pii:S0168-8278(17)32430-3. DOI:0.1016/j.jhep.2017.11.008. |
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