营养与肝再生

doi:10.3969/j.issn.1672-5069.2017.05.004

实用肝脏病杂志 ›› 2017, Vol. 20 ›› Issue (5): 523-526.doi: 10.3969/j.issn.1672-5069.2017.05.004

营养与肝再生

姬静，李荣山，任锋，时红波

030001 太原市山西医科大学（姬静，李荣山）；首都医科大学附属北京佑安医院北京市肝病研究所（任锋，时红波）

收稿日期:2017-07-01 出版日期:2017-10-10 发布日期:2017-10-17
通讯作者: 时红波，E-mail：shb411@126.com
作者简介:姬静，女，25岁，硕士研究生。主要从事肝肾损伤与肝再生研究。E-mail：jingji1019@163.com
基金资助:
国家自然科学基金资助项目（编号：81300349/81270532）；北京市自然科学基金资助项目（编号：7172102/7162085/7144216）；北京市科技新星计划项目（编号：Z131107000413016）；北京市卫生系统高层次卫生技术人才培养基金资助项目（编号：2014-3-090/2013-3-075）；北京市属医学科研院所公益发展改革试点项目（编号：京医研2016-2）

Impact of nutrition on liver regeneration

Ji Jing，Li Rongshan，Ren Feng，et al.

Shanxi Medical University, Taiyuan 030001, Shanxi Province

Received:2017-07-01 Online:2017-10-10 Published:2017-10-17

摘要/Abstract

关键词: 肝再生, 营养, 葡萄糖, 脂肪, 氨基酸

Key words: Liver Regeneration, Nutrition, Glucose, Fat, Amino acids

姬静，李荣山，任锋，时红波. 营养与肝再生[J]. 实用肝脏病杂志, 2017, 20(5): 523-526.

Ji Jing，Li Rongshan，Ren Feng，et al.. Impact of nutrition on liver regeneration[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2017, 20(5): 523-526.

[1] Fontburgada J，Shalapour S，Ramaswamy S，et al. Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer. Cell，2015，162（4）:766.
[2] Cheung K，Lee SS，Raman M. Prevalence and mechanisms of malnutrition in patients with advanced liver disease，and nutrition management strategies. Clin Gastroenterol Hepatol，2012，10（2）:117.
[3] Bemeur C，Desjardins P，Butterworth RF. Role of nutrition in the management of hepatic encephalopathy in end-stage liver failure. Nutr Metab，2010，2010:489823.
[4] Hiroyuki K，Zhang RR，Yasuharu U，et al. Nutritional modulation of mouse and human liver bud growth through a branched-amino acid metabolism. Development，2017，[ahead of print].
[5] Bukowiecki R， Adjaye J， Prigione A. Mitochondrial function in pluripotent stem cells and cellular reprogramming. Gerontology，2014，60（2）:174-182.
[6] Rondanelli M，Opizzi A，Antoniello N，et al. Effect of essential amino acid supplementation on quality of life，amino acid profile and strength in institutionalized elderly patients. Clin Nutrit，2011，30（5）:571-577.
[7] Kim SJ，Kim DG，Lee MD. Effects of branched-chain amino acid infusions on liver regeneration and plasma amino acid patterns in partially hepatectomized rats. Hepatogastroenterology，2011，58（109）:1280.
[8] Holecek M. Three targets of branched-chain amino acid supplementation in the treatment of liver disease. Nutrition，2010，26（5）:482-490.
[9] Toshiro M，Ken S，Shohei Y，et al. Nutrition support and infections associated with hepatic resection and liver transplantation in patients with chronic liver disease. JPEN，2013，37（3）:318-326.
[10] Alexander W，Eric H，Vered G，et al. p21 is required for dextrose-mediated inhibition of mouse liver regeneration. Hepatology，2009，50（1）:207-215.
[11] Valdecantos MP，Pardo V，Ruiz L，et al. A novel glucagon-like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice. Hepatology，2017，65（3）:950.
[12] Chen H，Lin Y，Sun W，et al. Liver regeneration is impaired in mice with acute exposure to a very low carbohydrate diet. Digest Dis Sci，2017，62（5）:1256-1264.
[13] Margonis GA，Amini N，Buettner S，et al. Impact of perioperative phosphorus and glucose levels on liver regeneration and long-term outcomes after major liver resection. J Gastrointest Surg，2016，20（7）:1305-1316.
[14] Hassanain M，Schricker T，Metrakos P，et al. Hepatic protection by perioperative metabolic support.Nutrition，2008，24（11）:1217-1219.
[15] Yang SQ，Lin HZ，Mandal AK，et al. Disrupted signaling and inhibited regeneration in obese mice with fatty livers:implications for nonalcoholic fatty liver disease pathophysiology. Hepatology，2001，34（1）:694-706.
[16] Stauffer JK，Scarzello AJ，Jiang Q，et al. Chronic inflammation，immune escape，and oncogenesis in the liver:A unique neighborhood for novel intersections. Hepatology，2012，56（4）:1567. [17] Truant S，Bouras AF，Petrovai G，et al. Volumetric gain of the liver after major hepatectomy in obese patients:a case-matched study in 84 patients. Ann Surg，2013，258（5）:702-704.
[18] Hamano M，Ezaki H，Kiso S，et al. Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis. J Gastroenterol，2014，49（2）:305-316.
[19] Inaba Y，Furutani T，Kimura K，et al. Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice. Hepatology，2015，61（4）:1343-1356.
[20] Jahn D，Rau M，Hermanns HM，et al. Mechanisms of enterohepatic fibroblast growth factor 15/19 signaling in health and disease. Cytok Growth Factor Rev，2015，26（6）:625-635.
[21] Hoppe S，Von LC，Lock JF，et al. Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery. J Investigat Surg，2015， 28（1）:24.
[22] Alvarezsola G，Uriarte I，Latasa MU，et al. Fibroblast growth factor 15/19（FGF15/19） protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration. Gut，2017，[ahead of print].
[23] Venu M，Martin E，Saeian K，et al. High prevalence of vitamin A and D deficiency in patients evaluated for liver transplantation. Liver Transplant，2013，19（6）:627.
[24] Bitetto D，Bortolotti N，Falleti E，et al. Vitamin A deficiency is associated with hepatitis C virus chronic infection and with unresponsiveness to interferon-based antiviral therapy. Hepatology，2013， 57（3）:925-933.
[25] Chantal B，Butterworth RF. Nutrition in the management of cirrhosis and its neurological complications. J Clin Exp Hepatol，2015， 5（1）:131-140.
[26] Carlett H，Ramírez-Farías S，Eduardo A，et al. Protective effect of some vitamins against the toxic action of ethanol on liver regeneration induced by partial hepatectomy in rats. World J Gastroenterol，2008，14（6）:899-907.
[27] Lin M，Sun P，Zhang G，et al. Vitamin K2-enhanced liver regeneration is associated with oval cell expansion and up-regulation of matrilin-2 expression in 2-AAF/PH rat model. Curr Mol Med，2014，14（3）:361.
[28] Laarschot LF，Jansen PLM，Schaap FG，et al. The role of bile salts in liver regeneration. Hepatol Int，2016，10（5）:1-8.
[29] Liu H X，Keane R，Sheng L，et al. Implications of microbiota and bile acid in liver injury and regeneration. J Hepatol，2015，63（6）:1502-1510.

营养与肝再生

Impact of nutrition on liver regeneration

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