慢加急性乙型肝炎肝衰竭患者血清IL-10和GP73水平检测及其临床意义

doi:10.3969/j.issn.1672-5069.2019.01.020

摘要/Abstract

摘要： 目的探讨HBV相关慢加急性肝衰竭（HBV-ACLF）患者血清IL-10和GP73水平变化及其临床意义。方法在56例HBV-ACLF患者、32例慢性乙型肝炎（CHB）患者和20例健康人,采用酶联免疫吸附法检测基线血清IL-10和GP73水平。随访HBV-ACLF患者3个月,进行重复检测。结果基线时HBV-ACLF组血清IL-10水平为（32.4±14.8） pg/ml,显著高于CHB组的（15.2±6.3） pg/ml或健康人的（6.1±1.9） pg/ml （P<0.05）; HBV-ACLF组血清GP73 水平为（283.4±95.4） ng/ml,显著高于CHB组的（129.7±58.1） ng/ml或健康人的（45.5±16.2） ng/ml （P<0.05）;33例生存的HBV-ACLF患者基线血清IL-10 水平为（34.6±15.3） pg/ml,显著高于23例死亡患者的（30.1±14.3） pg/ml（P<0.05）,但生存组与死亡组血清GP73水平差异无统计学意义【（279.7±94.6） ng/ml 对（287.2±96.2） ng/ml,P=0.36】;治疗2周时,HBV-ACLF生存组血清IL-10水平为（30.1±14.0） pg/ml,仍显著高于死亡组的（24.9±11.2） pg/ml（P<0.05）,但不同于基线时,治疗2周时生存与死亡患者血清GP73水平出现了统计学差异【（258.7±85.9） ng/ml对（331.2±107.5） ng/ml,P<0.05】。结论 HBV-ACLF患者血清IL-10 水平高者可能预后相对较好,而动态观察血清GP73水平变化可能对预测HBV-ACLF患者的短期预后也有一定的价值。

关键词: 慢加急性肝衰竭, 白细胞介素-10, 高尔基体蛋白73

Abstract: Objective To investigate the implication of serum IL-10 and GP73 levels in patients with HBV-related acute-on-chronic liver failure（HBV-ACLF）. Methods Serum IL-10 and GP73 levels were measured by ELISA in fifty-six patients with HBV-ACLF,thirty-two patients with chronic hepatitis B （CHB）,and twenty healthy persons. All patients with HBV-ACLF were followed-up for 3 months. Results At presentation,serum IL-10 level in patients with HBV-ACLF were （32.4±14.8） pg/ml,significantly higher than （15.2±6.3） pg/ml in patients with CHB or（6.1±1.9） pg/ml in healthy control （P<0.05）,and serum GP73 level in patients with HBV-ACLF were （283.4±95.4） ng/ml,also significantly higher than （129.7±58.1） ng/ml in patients with CHB or （45.5±16.2） ng/ml in the control（P<0.05）;at baseline,serum IL-10 levels in 33 survivals with HBV-ACLF were （34.6±15.3） pg/ml,significantly higher than（30.1±14.3） pg/ml in 23 dead ones（P<0.05）,and there was no significant difference between the survival and the dead as respect to their serum GP73 levels [（279.7±94.5） ng/ml vs. （287.2±96.2） ng/ml,P=0.36];two weeks after treatment,serum IL-10 levels in survival group with HBV-ACLF were （30.1±14.0） pg/ml,still significantly higher than （24.9±11.2） pg/ml in dead group （P<0.05）,and there was a significant difference of serum GP73 levels in the survival and dead [（258.7±85.9） ng/ml vs.（331.2±107.5） ng/ml,P<0.05]. Conclusion The HBV-ACLF patients with high serum IL-10 level might have a relatively good prognosis,and the dynamic detection of serum GP73 level might be of certainly significance in assessing short-term prognosis of patients with HBV-ACLF.

Key words: Acute-on-chronic liver failure, IL-10, GP73

陈海鸥, 刘适. 慢加急性乙型肝炎肝衰竭患者血清IL-10和GP73水平检测及其临床意义[J]. 实用肝脏病杂志, 2019, 22(1): 73-76.

Chen Haiou, Liu Shi.. Implication of serum IL-10 and GP73 levels in patients with HBV-related acute-on-chronic liver failure[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(1): 73-76.

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