关键词: 肝损害, 登革热, 血清铁蛋白, 多因素Logistic回归分析

Abstract: Objective The aim of this study was to explore the implication of serum ferritin (SF) levels in patients with Dengue fever. Methods 65 patients with Dengue fever at acute fever phase, including typical patients in 43 cases, severe type in 22 cases and with liver injury in 31 cases, were encountered in our hospital between October 2021 and October 2022. Serum SF and C-reactive protein (CRP) levels were routinely detected. The patients with liver injury were carefully managed with liver-protecting medicines. The multivariate Logistic regression analysis was applied to reveal the risk factors for the occurrence of severe type of the entity. Results Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), SF, CRP levels and platelet (PLT) count in patients with severe Dengue fever were (113.3±36.1)U/L, (93.2±22.4)U/L, (2214.4±519.3)ng/mL, (54.7±1.6)mg/L and (33.1±10.9)×10⁹/L, and in patients with liver injury were (86.3±7.1)U/L, (74.2±7.9)U/L,(1935.4±568.2)ng/mL, (33.2±3.2)mg/L and (55.4±11.7)×10⁹/L, they all decreased or got back to normal at the convalescent stage; the multivariate Logistic regression analysis showed that the greatly increased serum SF levels and the decreased PLT counts were the risk factors for the occurrence of severe Dengue fever(P<0.05); serum AST and ALT levels peaked at one week of onset of the disease, and gradually returned to normal, without liver failure happening. Conclusion Serum SF level increase in patients with Dengue fever, which might hint liver injury or even deterioration of the disease, and needs carefully monitored.

Key words: Liver injury, Dengue fever, Ferritin, Logistic regression