关键词: 胆石症, 代谢综合征, 腰围, 甘油三酯, 高密度脂蛋白, 老年

Abstract: Objective To investigate the prevalence metabolic syndrome（MS） and new-onset cholelithiasis in the elderly and to analyze the risk factors affecting the occurrence of cholelithiasis. Methods 508 elderly individuals underwent physical examination in our hospital between January 2013 and December 2017. According to generally approved criteria,246 patients were found to have MS,and 262 haven’t,respectively. The demographic data,height,body mass,waist circumference,blood pressure,blood biochemical parameters,e.g. fasting blood glucose（GLU）,triglyceride （TG） and high density lipoprotein （HDL） were collected. The multivariate Logistic analysis was applied to find out the risk factors for the occurrence of cholelithiasis in the elderly persons. Results There was no significant difference in the age of individuals between the two groups（P>0.05）;The BMI,systolic blood pressure,diastolic blood pressure and waist circumference in patients with MS were（27.0±3.0） kg/m²,（147.7±18.7） mmHg,（93.8±10.8） mmHg and（93.8±7.4） cm, significantly higher than[（24.1±2.8） kg/m²,（132.7±19.60） mmHg,（86.2±11.9） mmHg and （84.6±8.5） cm] in individuals without MS（P<0.05）;blood glucose and TG levels in patients with MS were（6.5±1.9） mmol/L and（2.3±1.7） mmol/L,respectively,significantly higher than [（5.6±1.3） mmol/L and （1.1±0.6） mmol/L in persons without MS （P<0.05）,while blood HDL in patients with MS was（1.3±0.8） mmol/L,significantly lower than [（1.6±0.4） mmol/L,P<0.05] in persons without MS; the prevalence of cholelithiasis in patients with MS was 19.1%,significantly higher than 3.4% in individuals without MS（x²=31.765,P<0.05）;there was no significant difference as respect to mean age between 56 patients with cholelithiasis and 452 individuals without （P>0.05）;the BMI,systolic blood pressure,diastolic blood pressure and waist circumference in patients with cholelithiasis were （27.6±3.9） kg/m²,（146.5±19.4） mmHg,（95.3±12.2） mmHg and （98.5±8.9） cm,significantly higher than [（25.3±3.2） kg/m²,（139.4±20.6） mmHg,（89.5 ±11.9） mmHg and （90.8±9.7） cm,P<0.05] in persons without cholelithiasis（P<0.05）;blood glucose and TG levels in patients with cholelithiasis were （6.8±1.7） mmol/L and （1.7±1.4） mmol/L,significantly higher than [（5.9±1.6） mmol/L and （1.6±1.3） mmol/L,P<0.05] in persons without, while blood HDL level was（1.2±0.4） mmol/L,significantly lower than[（1.5±0.6） mmol/L,P<0.05] in persons without;the binary Logistic multivariate regression analysis showed that the waist circumference,blood GLU and TG levles were the independent risk factors for cholelithiasis occurrence. Conclusion Metabolic syndrome is positively associated with new-onset cholelithiasis in the elderly population and the waist circumference,blood glucose and TG levels are the independent risk factors for new-onset occurrence of cholelithiasis in the elderly,which should be concerned in clinical practice.

Key words: Cholelithiasis, Metabolic syndrome, Waist circumference, Triglyceride, High density lipoprotein, Elderly