阿德福韦酯治疗不同HBV基因型感染慢性乙型肝炎患者48周疗效分析*

doi:10.3969/j.issn.1672-5069.2011.06.007

实用肝脏病杂志 ›› 2011, Vol. 14 ›› Issue (6): 417-419.doi: 10.3969/j.issn.1672-5069.2011.06.007

阿德福韦酯治疗不同HBV基因型感染慢性乙型肝炎患者48周疗效分析^*

叶珺,郜玉峰,魏艳艳,夏国美,李芳,李旭

230601 合肥市安徽医科大学第二附属医院肝病科

收稿日期:2011-08-01 出版日期:2011-12-15 发布日期:2016-04-14
通讯作者: 李旭 aylixu@yahoo.com.cn
作者简介:叶峻女，39岁，医学硕士，副主任医师。E-mail：yejun2004088@yahoo.com.cn
基金资助:
国家自然科学基金资助课题（编号：81072342）

The efficacy of adefovir dipivoxil on patients with chronic hepatitis B and its association with HBV genotypes

YE Jun，GAO Yufeng，WEI Yanyan，et al.

Department of Hepatology，The Second Affiliated Hospital， Anhui Medical University，Hefei 230601，China

Received:2011-08-01 Online:2011-12-15 Published:2016-04-14
Contact: LI Xu，E-mail:aylixu@yahoo.com.cn

摘要/Abstract

摘要： 目的观察阿德福韦酯初始治疗慢性乙型肝炎患者48周疗效及其与HBV基因型的关系。方法 75例慢性乙型肝炎患者接受国产阿德福韦酯治疗48周，观察治疗期间ALT、AST、HBV DNA、HBeAg等指标变化，并检测患者HBV基因型。结果在75例中检出B基因型49例（65.3%），C基因型22例（29.3%），B/C基因型4例（5.3%）；治疗48周时ALT复常率和HBV DNA转阴率分别为58.7%和50.7%，HBeAg消失率为34.9%，HBeAg血清转换率为1.5%；在治疗12周时，B基因型组ALT复常率和HBV DNA阴转率分别为26.5%和38.8%，48周时为55.1%和53.1%，在治疗12周时，C基因组ALT复常率和HBV DNA阴转率为13.6%和31.8%，48周为59.1%和36.4%（P＞0.05）。结论基线HBV DNA>1×105copies/ml的慢性乙型肝炎患者初始采用ADV治疗，HBeAg血清学转换率较低，ADV治疗的疗效与HBV基因型无关。

Abstract: Objective To evaluate the efficacy of adefovir dipivoxil（ADV） on patients with chronic hepatitis B，and its association with HBV genotypes.Methods 75 patients with chronic hepatitis B were treated with ADV for 48 weeks，and the HBV genotypes were detected.Results In all patients，HBV genotype B，C and B/C were 49（65.4%），22（29.3%） and 4（5.3%），respectively;ALT normalization and HBV DNA negative rates at week 48 were 58.7% and 50.7%，HBeAg loss and HBeAg seroconversion rates were 34.9% and 1.5%，respectively;The ALT normalization and HBV DNA negative rate in genotype B group at week 12 were 26.5% and 38.8%， which came to 55.1% and 53.1% at week 48，respectively，while in genotype C group at 12 week were 13.6% and 31.8%，which came to 59.1% and 36.4% at 48 week，respectively.Conlusions The baseline HBV DNA levels affect the antiviral response to ADV，especially in patiens with HBV DNA>1×105copies/ml.There was no association between the efficacy of adefovir dipivoxil and HBV genotypes.

Key words: Hepatitis B, Adefovir dipivoxil, HBV genotypes

叶珺,郜玉峰,魏艳艳,夏国美,李芳,李旭. 阿德福韦酯治疗不同HBV基因型感染慢性乙型肝炎患者48周疗效分析^*[J]. 实用肝脏病杂志, 2011, 14(6): 417-419.

YE Jun，GAO Yufeng，WEI Yanyan，et al.. The efficacy of adefovir dipivoxil on patients with chronic hepatitis B and its association with HBV genotypes[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2011, 14(6): 417-419.

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阿德福韦酯治疗不同HBV基因型感染慢性乙型肝炎患者48周疗效分析^*

The efficacy of adefovir dipivoxil on patients with chronic hepatitis B and its association with HBV genotypes

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