[1] HONKOOP P,DE MAN RA. Entecavir:a potent new antiviral drug for hepatitis B[J]. Expert Opin Investig Drugs,2003,12:683-688. [2] TENNEY DJ,ROSE RE,BALDICK CJ,et al. Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naive patients is rare through 5 years of therapy[J]. Hepatology,2009,49:1503-1514. [3] COLONNO RJ,ROSE RE,POKORNOWSKI K,et al.Assessment at three years shows high barrier to treated nucleoside naive patients while resistance emergence increases over time in lamivudine refractory patients[J]. Hepatology,2006,44 Suppl 1:229A-230A. [4] 中华医学会肝病学分会和感染病学分会. 慢性乙型肝炎防治指南[J]. 实用肝脏病杂志,2006,9(1):8-18. [5] LIAW YF,SUNG JJ,CHOW WC,et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease[J]. N Engl J Med,2004,351(15):1521-31. [6] EUN JR. Comparison of clinical outcome between patients continuing and discontinuing lamivudine therapy in acute exacerbation after viral breakthrough during lamivudine therapy in chronic hepatitis B[J]. Korean J Hepatol,2006,12(2):184-90. [7] 任红. 乙型肝炎病毒耐药管理的新观念[J]. 中华肝脏病杂志,2008,16(5):329-334. [8] BONI C,BERTOLETTI A,PENNA A,et al. Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B[J]. J Clin Invest,1998,102:968-975. [9] 刘密霞,鲍晚籽,来瑞娟. 血清HBVDNA和丙氨酸氨基转移酶水平与干扰素α-1b治疗慢性乙型肝炎疗效的关系[J]. 实用肝脏病杂志,2009,12(2):104-105. [10] 杨方,吴晓枫,李兴海,等. 聚乙二醇干扰素α-2b治疗慢性乙型肝炎获得HBsAg血清转换3例[J]. 中华肝脏病杂志,2009,17(12):950-951. [11] 王宇明,张绪清,向德栋. 亚太肝脏研究学会《慢性乙型肝炎治疗指南》2008版简介及评述[J]. 中华临床感染病杂志,2008,2(1):122-126. |