Abstract: Objective The purpose of this study was to investigate measurement of liver volumes by computed tomography (CT) scans in patients with hepatitis B-induced liver cirrhosis of different Child-Pugh class. Methods A total of 126 patients with hepatitis B liver cirrhosis, including Child-Pugh class A in 37 cases, class B in 58 cases and class C in 31 cases, and 50 healthy individuals for physical examination were encountered in our hospital between October 2020 and October 2022, and all underwent enhanced CT scans. Liver volumes were measured by software Volume at Syngo Acquisition station. Results Total liver volumes in patients with Child-Pugh class A, B and C were (1101.3±285.2) m³, (984.7±240.1) m³ and (875.9±228.7) m³, left inner lobe volumes were (142.8±39.1) m³, (133.9±26.8) m³ and (117.2±32.6) m³, right anterior lobe volumes were (305.2±84.5) m³, (323.6±71.9) m³ and (281.3±60.2) m³, and right posterior lobe volumes were (242.3±74.2) m³ , (236.5±58.6) m³ and (213.7±56.8) m³, all significantly smaller than [(1227.5±267.6) m³, (182.5±47.3) m³ , (468.3±82.6) m³ and (349.7±81.2) m³, P<0.05] in healthy persons; left lateral lobe volumes in patients with Child-Pugh class A, B, and C were (362.7±75.8) m³, (248.4±72.3) m³ and (225.6±68.2) m³, caudate lobe volumes were (48.3±11.6) m³, (42.3±10.5) m³ and (38.1±10.9) m³, all significantly larger than [194.6±45.9) m³ and (32.4±10.6) m³, P<0.05] in healthy persons; proportions of left lateral lobe to whole liver volumes in patients with Child-Pugh class A, B and C were (30.2±6.3)%, (29.3±6.1)% and (28.9±5.3)%, proportions of caudate lobe were (3.5±1.1)%, (3.3±0.9)% and (2.8±0.6)%, all significantly greater than [19.3±2.5)% and (1.8±0.3)%, P<0.05] in healthy control; proportions of right anterior lobes in patients with Child-Pugh class A, B and C were (30.2±4.3)%, (28.7±4.8)% and (29.3±5.1)%, while the proportions of right posterior lobes were (20.8±3.7)%, (23.7±2.1)% and (23.3±2.4)%, all significantly lower than (35.5±5.4)% and (27.1±2.5)%, respectively, P<0.05) in healthy individuals; by Spearman rank correlation coefficient analysis, there was a negative correlation between Child-Pugh classification and total liver volumes in patients with hepatitis B-induced liver cirrhosis (r=-0.562, P<0.05). Conclusion The total liver volumes measured by CT scan in patients with hepatitis B-induced liver cirrhosis decrease as compared to in healthy individuals, which means a reduced liver function reservoir.

Key words: Liver cirrhosis, Liver volumes, Child-Pugh class, CT scan