Abstract: Objective This study aimed to investigate the etiologies and complications in adults with liver cirrhosis (LC) in First Hospital, Peking University (Center A) and Guizhou Provincial People's Hospital (Center B). Methods A total of 1813 patients with LC in Center A, 388 LC patients in Center B were hospitalized between January 2018 and December 2020, and after exclusion, 700 patients (including hepatitis B in 252 cases) in the former and 340 patients (HBV infection in 137 cases) in the latter were enrolled in this study. Results The common causes of LC in the two centers were hepatitis B, hepatitis C, alcoholic liver diseases (ALD), primary biliary cirrhosis and autoimmune hepatitis, with some uncommon etiologies, such as drug-induced liver injury, inherited metabolic liver disease and cryptogenic liver diseases; the ALD accounted for 23.2% and hepatitis B with concomitant ALD for 17.7% in Center B, both significantly higher than 13.0% and 4.1% (P<0.05) in Center A; incidence of hepatocellular carcinoma in Center A was 27.0%, much higher than 14.1%(P<0.05) in Center B, while the percentages of patients with esophagogastric varices, ascites, infections and Child-Pugh class C in Center B were 61.5%, 80.6%, 50.9% and 52.1%, all much higher than 43.4%, 39.3%, 17.4% and 14.1%(P<0.05) in Center A. Conclusion The main causes of LC in China are still HBV infection and ALD, which varied a little in different regions, and patients in some areas might have a poor liver function states, more complications and need more attentions.

Key words: Liver cirrhosis, Etiology, Complications